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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25561802</PMID><DateCompleted><Year>2015</Year><Month>09</Month><Day>14</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2219-2840</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>48</Issue><PubDate><Year>2014</Year><Month>Dec</Month><Day>28</Day></PubDate></JournalIssue><Title>World journal of gastroenterology</Title><ISOAbbreviation>World J Gastroenterol</ISOAbbreviation></Journal><ArticleTitle>T helper cell dysregulation with hepatitis B and rebalance with glucocorticoids.</ArticleTitle><Pagination><StartPage>18354</StartPage><EndPage>18359</EndPage><MedlinePgn>18354-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3748/wjg.v20.i48.18354</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To investigate T helper 17/regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The study included 20 patients in the early stage of severe hepatitis B (SHB) and 11 healthy controls. All patients had elevated T helper 17 (Th17) levels, decreased regulatory T (Treg) cell levels, and significant Th17/Treg ratios.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After glucocorticoid treatment, 16 patients showed improvement with significant decreases in Th17 levels, increases in Treg, and rebalanced Th17/Treg ratios. The four patients who showed no improvement had increases in both Th17 and Treg levels and an even higher Th17/Treg ratio than before.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Glucocorticoid treatment can rectify Th17/Treg dysregulation in patients with SHB.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Zhong-Hua</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Xiao-Ping</ForeName><Initials>XP</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yi-Ling</ForeName><Initials>YL</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cui</LastName><ForeName>Juan-Juan</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Li-Hua</ForeName><Initials>LH</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuai</LastName><ForeName>Shou-Gang</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>He-Juan</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ju</LastName><ForeName>Zhao-Xia</ForeName><Initials>ZX</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gan</LastName><ForeName>Jian-He</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Zhong-Hua Lu, Xiao-Ping Huang, Wei Sun, Yi-Ling Zhu, Juan-Juan Cui, Jian-He Gan, Department of Infectious Disease, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>World J Gastroenterol</MedlineTA><NlmUniqueID>100883448</NlmUniqueID><ISSNLinking>1007-9327</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>X4W7ZR7023</RegistryNumber><NameOfSubstance UI="D008775">Methylprednisolone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005938" MajorTopicYN="N">Glucocorticoids</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006509" MajorTopicYN="N">Hepatitis B</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018655" MajorTopicYN="N">Lymphocyte Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008775" MajorTopicYN="N">Methylprednisolone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D050378" MajorTopicYN="N">T-Lymphocytes, Regulatory</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058504" MajorTopicYN="N">Th17 Cells</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dysregulation</Keyword><Keyword MajorTopicYN="N">Glucocorticoid</Keyword><Keyword MajorTopicYN="N">Regulatory T cell</Keyword><Keyword MajorTopicYN="N">Severe hepatitis B</Keyword><Keyword MajorTopicYN="N">T helper 17 cell</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>4</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>6</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>7</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>1</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2014</Year><Month>12</Month><Day>28</Day></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25561802</ArticleId><ArticleId IdType="pmc">PMC4277972</ArticleId><ArticleId IdType="doi">10.3748/wjg.v20.i48.18354</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Lee WM, Sorrell MF. Developing a World view toward acute liver failure. Hepatology. 1996;24:270&#x2013;271.</Citation><ArticleIdList><ArticleId IdType="pubmed">8707275</ArticleId></ArticleIdList></Reference><Reference><Citation>Lee KC, Palacios Jimenez C, Alibhai H, Chang YM, Leckie PJ, Baker LA, Stanzani G, L Priestnall S, Mookerjee RP, Jalan R, et al. A reproducible, clinically relevant, intensively managed, pig model of acute liver failure for testing of therapies aimed to prolong survival. Liver Int. 2013;33:544&#x2013;551.</Citation><ArticleIdList><ArticleId IdType="pubmed">23331547</ArticleId></ArticleIdList></Reference><Reference><Citation>Moon YM, Lee J, Lee SY, Her YM, Ryu JG, Kim EK, Son HJ, Kwok SK, Ju JH, Yang CW, et al. Gene associated with retinoid-interferon-induced mortality 19 attenuates murine autoimmune arthritis by regulation of th17 and treg cells. Arthritis Rheumatol. 2014;66:569&#x2013;578.</Citation><ArticleIdList><ArticleId IdType="pubmed">24574216</ArticleId></ArticleIdList></Reference><Reference><Citation>Dong X, Gong Y, Zeng H, Hao Y, Wang X, Hou J, Wang J, Li J, Zhu Y, Liu H, et al. Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV-related acute-on-chronic liver failure. Liver Int. 2013;33:1517&#x2013;1526.</Citation><ArticleIdList><ArticleId IdType="pubmed">23869954</ArticleId></ArticleIdList></Reference><Reference><Citation>Singh A, Vajpayee M, Ali SA, Chauhan NK. Cellular interplay among Th17, Th1, and Treg cells in HIV-1 subtype &#x201c;C&#x201d; infection. J Med Virol. 2014;86:372&#x2013;384.</Citation><ArticleIdList><ArticleId IdType="pubmed">24249618</ArticleId></ArticleIdList></Reference><Reference><Citation>O&#x2019;Grady J. Bioartificial liver in acute liver failure: impostor or simply misunderstood? Hepatology. 2005;41:383&#x2013;385.</Citation><ArticleIdList><ArticleId IdType="pubmed">15578652</ArticleId></ArticleIdList></Reference><Reference><Citation>Hughes RD, Nagaki M, Keane H, Sheron N, Williams R. Artificial liver support in acute liver failure: a review of studies at King&#x2019;s. Artif Organs. 1992;16:167&#x2013;170.</Citation><ArticleIdList><ArticleId IdType="pubmed">10078239</ArticleId></ArticleIdList></Reference><Reference><Citation>Zhang GL, Xie DY, Lin BL, Xie C, Ye YN, Peng L, Zhang SQ, Zhang YF, Lai Q, Zhu JY, et al. Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure. J Gastroenterol Hepatol. 2013;28:513&#x2013;521.</Citation><ArticleIdList><ArticleId IdType="pubmed">23215950</ArticleId></ArticleIdList></Reference><Reference><Citation>Joseph B. Liver failure. In: Moore FO, Rhee PM, Tisherman SA, Fulda GJ, editors. Liver failure. Surgical critical care and emergency surgery: clinical questions and answers. Chichester UK: John Wiley; 2012. pp. 165&#x2013;171.</Citation></Reference><Reference><Citation>Knisely AS. Patent ductus venosus and acute liver failure in the neonate: consider neonatal hemochromatosis with liver scarring. Liver Transpl. 2014;20:124.</Citation><ArticleIdList><ArticleId IdType="pubmed">24136749</ArticleId></ArticleIdList></Reference><Reference><Citation>Ye YN, Gao ZL. [Three shock hypotheses that may induce liver failure] Zhonghua Ganzangbing Zazhi. 2009;17:638&#x2013;640.</Citation><ArticleIdList><ArticleId IdType="pubmed">19719932</ArticleId></ArticleIdList></Reference><Reference><Citation>Kelly D, Bremner R, Hartley J, Flynn D. The management of a child with acute liver failure. In: Deirdre K, Ronald B, Jane H, Diana F, editors. Hepatology and nutrition. Oxford UK: John Wiley; 2013. pp. 158&#x2013;163.</Citation></Reference><Reference><Citation>Rajanayagam J, Coman D, Cartwright D, Lewindon PJ. Pediatric acute liver failure: etiology, outcomes, and the role of serial pediatric end-stage liver disease scores. Pediatr Transplant. 2013;17:362&#x2013;368.</Citation><ArticleIdList><ArticleId IdType="pubmed">23586473</ArticleId></ArticleIdList></Reference><Reference><Citation>Gu FM, Li QL, Gao Q, Jiang JH, Zhu K, Huang XY, Pan JF, Yan J, Hu JH, Wang Z, et al. IL-17 induces AKT-dependent IL-6/JAK2/STAT3 activation and tumor progression in hepatocellular carcinoma. Mol Cancer. 2011;10:150.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3310750</ArticleId><ArticleId IdType="pubmed">22171994</ArticleId></ArticleIdList></Reference><Reference><Citation>Sehgal R, David P, Vyas A, Rawal P, Hissar S, Samudrala G, Patra S, Trivedi S, Sarin S, Trehanpati N. Reduction in CD4 T cells and altered monocytes/macrophages is associated with fatal acute liver failure hepatitis E virus infected pregnant patients. J Viral Hepat. 2013;20:39&#x2013;40.</Citation></Reference><Reference><Citation>Tuncer C, Oo YH, Murphy N, Adams DH, Lalor PF. The regulation of T-cell recruitment to the human liver during acute liver failure. Liver Int. 2013;33:852&#x2013;863.</Citation><ArticleIdList><ArticleId IdType="pubmed">23617240</ArticleId></ArticleIdList></Reference><Reference><Citation>Park JS, Lim MA, Cho ML, Ryu JG, Moon YM, Jhun JY, Byun JK, Kim EK, Hwang SY, Ju JH, et al. p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum. 2013;65:949&#x2013;959.</Citation><ArticleIdList><ArticleId IdType="pubmed">23280308</ArticleId></ArticleIdList></Reference><Reference><Citation>Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunol Rev. 2013;252:52&#x2013;77.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3576873</ArticleId><ArticleId IdType="pubmed">23405895</ArticleId></ArticleIdList></Reference><Reference><Citation>Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, Jin HT, Min SY, Ju JH, Park KS, et al. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol. 2006;176:5652&#x2013;5661.</Citation><ArticleIdList><ArticleId IdType="pubmed">16622035</ArticleId></ArticleIdList></Reference><Reference><Citation>Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB. The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem. 2013;288:4723&#x2013;4732.</Citation><ArticleIdList><ArticleId IdType="pmc">PMC3576077</ArticleId><ArticleId IdType="pubmed">23271731</ArticleId></ArticleIdList></Reference><Reference><Citation>Ikeda O, Mizushima A, Sekine Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T. Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells. Cancer Sci. 2011;102:756&#x2013;761.</Citation><ArticleIdList><ArticleId IdType="pubmed">21205088</ArticleId></ArticleIdList></Reference><Reference><Citation>Bansal MB. Acute liver failure. In: Ahmad J, Friedman SL, Dancygier H, editors. Hepatology. Oxford UK: John Wiley; 2014. pp. 280&#x2013;293.</Citation></Reference><Reference><Citation>Neuberger J. Management of the patient with fulminant hepatic failure awaiting liver transplantation. In: James N, James F, Philip NN, editors. Liver Transplantation. Oxford UK: John Wiley; 2013. pp. 93&#x2013;100.</Citation></Reference><Reference><Citation>Benyoub K, Muller M, Bonnet A, Simon R, Gazon M, Duperret S, Aubrun F, Viale JP. Amounts of bile acids and bilirubin removed during single-pass albumin dialysis in patients with liver failure. Ther Apher Dial. 2011;15:504&#x2013;506.</Citation><ArticleIdList><ArticleId IdType="pubmed">21974706</ArticleId></ArticleIdList></Reference><Reference><Citation>Barnabas A, O&#x2019;Grady J. Assessment of the patient with acute liver failure. In: Ashley B, John OG, editors. Liver transplantation: clinical assessment and management. Oxford UK: John Wiley; 2013. pp. 83&#x2013;92.</Citation></Reference><Reference><Citation>MacQuillan G. Predicting outcome in acute liver failure: are we there yet? Liver Transpl. 2007;13:1209&#x2013;1211.</Citation><ArticleIdList><ArticleId IdType="pubmed">17763397</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></PubmedArticle></PubmedArticleSet>