Screening of a marine natural products library afforded three new analogues of the tetronic acid containing polyketide abyssomicin family and identified abyssomicin 2 as a selective reactivator of latent HIV virus. Examination of the mode of action of this new latent HIV reactivating agent demonstrated that it functions via a distinct mechanism compared to that of existing reactivating agents and is effective at reactivating latent virus in a subset of primary patient cell lines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755699 | PMC |
| http://dx.doi.org/10.1021/ol503349y | DOI Listing |
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