Objectives: To examine diagnostic and treatment pathways for Māori (the indigenous people of New Zealand [NZ]) and NZ European men with prostate cancer in order to identify causes of higher mortality rates for Māori men.
Methods: All Māori men (150) diagnosed with prostate cancer in the Midland Cancer Network region between 2007 and 2010 were identified from the NZ Cancer Registry and frequency age-matched with three randomly sampled NZ European men. Clinical records of these men were searched for information on clinical stage at diagnosis, comorbidities, and type of treatment for localised disease.
Results: The final cohort included 136 Māori and 400 NZ European men, of whom 97 Māori and 311 NZ European were diagnosed with localised prostate cancer. Māori men were twice as likely to be diagnosed with distant metastases compared with NZ European men (19.1 vs 9.8 %). Māori men with localised disease were less likely to be treated with radical prostatectomy compared with NZ European men [RR 0.66 (95 % CI 0.48, 0.90)]. Multivariate regression analysis adjusted for age, D'Amico risk strata, comorbidities, and socioeconomic deprivation showed that Māori men were more likely to be managed expectantly [RR 1.74 (95 % CI 1.06, 2.57)].
Conclusion: Differences between Māori and NZ European men observed in the management of localised prostate cancer cannot be readily explained by patient characteristics, such as comorbidities or risk assessment at diagnosis. Poorer outcomes for Māori men may not only be related to later stage at diagnosis but differences in treatment modalities may also be a factor.
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http://dx.doi.org/10.1007/s10147-014-0781-4 | DOI Listing |
J Electromyogr Kinesiol
December 2024
Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno, Brno, Czechia; Faculty of Medicine, Masaryk University, Brno, Czechia; Department of Rehabilitation, University Hospital Brno, Brno, Czechia; Department of Public Health, Faculty of Medicine, Masaryk University, Brno, Czechia.
The purpose of this cross-sectional study was to present the values of maximal isometric lumbar extensor muscle strength (MILEMS) and lumbar extensor muscle endurance (LEME) in healthy subjects and to study the influence of physiological factors on these parameters. MILEMS using a hand-held dynamometer in three positions (prone, sitting, standing) and LEME using the Biering-Sørensen test were assessed in 115 healthy volunteers. The MILEMS measurements for the specific positions were correlated with each other (Pearson correlation coefficients 0.
View Article and Find Full Text PDFExplor Target Antitumor Ther
December 2024
Department of Thoracic Oncology, Georges Pompidou European Hospital, Paris Cité University, AP-HP, CARPEM, 75015 Paris, France.
Aim: Immune checkpoint inhibitors improved the survival of advanced non-small cell lung cancer. However, only 20% of patients respond to these treatments and the search for predictive biomarkers of response is still topical. The objective of this work is to analyze the anti-PD-1 monotherapy benefit based on genetic alterations diagnosed by next generation sequencing (NGS), in advanced non-small cell lung cancer.
View Article and Find Full Text PDFRationale: A scoping review was conducted to investigate knowledge gaps in the informatics research literature regarding sex differences in cognitive decline, identifying existing studies and areas where further studies are needed.
Materials And Methods: We searched Ovid and other databases for studies on sex differences and cognitive decline, focusing on publications in peer-reviewed informatics journals and conference proceedings from 2000 to 2023. The selected manuscripts were analyzed and summarized through discussion among three reviewers.
Ann N Y Acad Sci
January 2025
Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.
The majority of research on loneliness considers gender by comparing the loneliness reported by men and women. Drawing on current conceptualizations of gender and its effects, we propose alternative ways in which gender should be examined in relation to loneliness. To do so, we consider multiple gender-related factors and the role of the social environment, particularly societal ideologies about what gender is and how it should be expressed.
View Article and Find Full Text PDFCureus
December 2024
Urology, Northwick Park Hospital - London North West University Healthcare NHS Trust, Harrow, GBR.
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