Background: The Atopic Dermatitis Antecubital Severity (ADAS) score is a new objective scale for the assessment of the severity of atopic dermatitis (AD). It is calculated by multiplying the intensity of inflammatory signs by the size of an antecubital eczema lesion.
Aim: To test the validity, reliability, and sensitivity to changes of the ADAS score compared with those of the Eczema Area and Severity Index (EASI) score.
Methods: Forty patients with AD were enrolled and treated with a moisturizer. At baseline, and in weeks 1 and 2, two independent evaluators measured the ADAS score, the EASI score, and the investigator's global assessment score rated on a six-point scale.
Results: The ADAS score showed a higher validity than the EASI score. The superiority of the ADAS to the EASI was prominent in mild AD. Inter-evaluator reliability was excellent in both the ADAS score and the EASI. The sensitivity to changes was higher in the ADAS score than in the EASI score.
Conclusions: The ADAS score may be used as a simple scoring system with good validity, reliability, and sensitivity to changes, especially in patients with mild-to-moderate AD.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ijd.12711 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Massachusetts Chan Medical School, Worcester, MA, USA.
Background: Alzheimer's disease (AD) is the most common type of dementia which results in debilitating memory loss as the disease advances. However, among older adults with AD, some may experience rapid cognitive decline while others may maintain a stable cognitive status for years. In addition to the amyloid plaques, tau tangles, and neuronal inflammation characteristic of AD, there is strong evidence of dysregulation in the peripheral immune system, including decreased naïve T cells and increased memory T cells among older adults with AD.
View Article and Find Full Text PDFBackground: Changes in the structure and use of language are well established clinical characteristics of Alzheimer's disease. In recent years, there has been a concerted effort to objectively quantify these changes using the latest advances in Natural Language Processing (NLP) tools. Much academic research has been conducted to evaluate how these speech characteristics change with the course of illness, but they have yet to be elevated beyond exploratory endpoints in trials.
View Article and Find Full Text PDFBackground: Speech and language impairments are associated with cognitive decline in neurodegenerative dementias, particularly Alzheimer's Disease (AD), where subtle speech changes may precede clinical dementia onset. As clinical trials prioritize early identification for disease-modifying treatments, digital biomarkers for timely screening become imperative. Digital speech-based biomarkers can be employed for screening populations at the earliest AD stages.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of California Irvine, Irvine, CA, USA.
Background: Alzheimer's disease exhibits heterogeneity through varied phenotypic and pathological manifestations. Here, we aimed to investigate the potential of semi-supervised pattern classification applied to volumetric MRI data in identifying relatively homogeneous subgroups of individuals exhibiting cognitive decline (CD) throughout the study period.
Method: We used data from the placebo arm of trial of Solanezumab for mild dementia due to AD (EXPEDITION-3 trial).
Clinical Manifestations.
Alzheimers Dement
December 2024
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Background: The study aimed to evaluate the effects of four weeks of 500 nm blue-green light visual stimulation on cognition, mood, and sleep in patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).
Method: Eighty patients were recruited from the Memory Clinic. The experimental group comprised 42 cases (22 SCD and 20 MCI), while the control group comprised 38 cases (27 SCD and 11 MCI).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!