AI Article Synopsis
- The study combines advanced imaging and modeling techniques to reveal a clear link between the shape of nanopores and their ionic conductance, highlighting that geometry changes in solution can lead to differences between expected and actual measurements.
- It examines the structural integrity of different types of nanopores formed by ion beam sculpting, showing that annealing can enhance the stability of these nanopores.
- The research also discusses how chemical dissolution affects nanopore geometry and suggests that slight adjustments in the fabrication process can notably boost the stability of ion beam sculpted nanopores.
Article Abstract
In this work we use a combination of 3D-TEM tomography, energy filtered TEM, single molecule DNA translocation experiments, and numerical modeling to show a more precise relationship between nanopore shape and ionic conductance and show that changes in geometry while in solution can account for most deviations between predicted and measured conductance. We compare the structural stability of ion beam sculpted (IBS), IBS-annealed, and TEM drilled nanopores. We demonstrate that annealing can significantly improve the stability of IBS made pores. Furthermore, the methods developed in this work can be used to predict pore conductance and current drop amplitudes of DNA translocation events for a wide variety of pore geometries. We discuss that chemical dissolution is one mechanism of the geometry change for SiNx nanopores and show that small modification in fabrication procedure can significantly increase the stability of IBS nanopores.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288979 | PMC |
| http://dx.doi.org/10.1088/0957-4484/26/4/044001 | DOI Listing |
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