AI Article Synopsis
- Pituitary adenomas (PAs) are mostly benign tumors that require a combination of surgery, medication, and radiation for treatment, following a multidisciplinary approach.
- Trans-sphenoidal surgery is the primary treatment for PAs, except for those producing prolactin, but can be complicated by aggressive or invasive tumors, often necessitating medical therapies.
- The review focuses on both the molecular and clinical aspects of existing and developing medical treatments tailored to various types of pituitary adenomas.
Article Abstract
Pituitary adenomas (PA) represent in the majority of cases, benign tumors whose treatment currently associate surgery, medical therapies and radiotherapy in a multidisciplinary approach. While trans-sphenoidal surgery remains, except for prolactin-secreting adenomas, the first-line treatment of PA, it can considerably be hampered by the existence of an invasive and/or aggressive tumor for which medical therapies are often requested. In this review, we extensively discuss, both at molecular and clinical levels, the medical therapies currently used and in development in the different phenotypes of pituitary adenomas.
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| http://dx.doi.org/10.1016/j.ando.2014.10.002 | DOI Listing |
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