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A Case of Hepatocellular Carcinoma Complicated by Fulminant Type 1 Diabetes Mellitus Shortly After Initiation of Durvalumab Plus Tremelimumab.
Intern Med
December 2024
Department of Gastroenterology and Hepatology, Saitama Medical University, Japan.
A 64-year-old man with cirrhosis was diagnosed with unresectable hepatocellular carcinoma and treated with a combination of durvalumab and tremelimumab. The patient had no history of diabetes mellitus. Three weeks later, the patient developed general fatigue, dry mouth, and polyuria.
View Article and Find Full Text PDFFulminant type 1 diabetes mellitus: a neglected but high-risk adverse event associated with immune checkpoint inhibitors.
Expert Opin Drug Saf
December 2024
Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer treatment but is associated with fulminant type 1 diabetes mellitus (FT1DM). Our study aims to investigate the association between ICI therapy and FT1DM using the FDA Adverse Event Reporting System (FAERS) database.
Methods: We conducted a retrospective analysis from the first quarter of 2004 to the first quarter of 2023.
Brugada phenocopy in fulminant eosinophilic myocarditis: a case series.
Eur Heart J Case Rep
December 2024
Department of Cardiology, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama, Okayama 708-0841, Japan.
Background: Brugada phenocopy (BrP) is a condition that induces reversible Brugada-like electrocardiographic (ECG) changes in patients without true Brugada syndrome. We present two cases of fulminant eosinophilic myocarditis that showed Type 1 Brugada ECG changes in the early phase of the clinical course.
Case Summary: Case 1 was a 76-year-old man who developed fulminant eosinophilic myocarditis with ventricular tachycardia while hospitalized for heart failure.
Herpes Simplex Virus Type 2 Hepatitis: An Uncommon Cause of Persistent Fever in a Late Post-Transplant Liver Recipient.
Am J Case Rep
December 2024
Department of Hospital Internal Medicine, Mayo Clinic, Jacksonville, FL, USA.
BACKGROUND Herpes simplex virus (HSV) is a rare cause of hepatitis. HSV hepatitis can be life-threatening due to its rapid progression to liver failure if not treated on time. It affects primarily immunocompromised individuals but can also present in immunocompetent hosts.
View Article and Find Full Text PDFMultidisciplinary Approach in Rare, Fulminant-Progressing, and Life-Threatening Facial Necrotizing Fasciitis.
Infect Dis Rep
November 2024
Department Plastic Surgery and Reconstructive, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Article Synopsis
- - Necrotizing fasciitis is a serious and often deadly infection that usually involves multiple types of bacteria, needing flexible and complex treatment, particularly when it occurs on the face, which is less common but very severe.
- - A case study describes a patient with various health issues who developed rapid facial necrosis after nasal trauma, leading to critical health decline and complicated treatment, involving multiple surgeries from different specialists.
- - Early recognition and a collaborative approach are crucial for managing facial necrotizing fasciitis effectively, aiming to save lives and reduce lasting physical and cosmetic damage.
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