AI Article Synopsis
- - The study focuses on enhancing the synthesis process of dihydropyridinones using isothiourea catalysts, specifically through a unique Michael addition and lactamization technique.
- - Ketimines from α,β-unsaturated γ-ketoesters are used as Michael acceptors, resulting in the production of diverse dihydropyridinones with a high degree of enantioselectivity.
- - The research explores the influence of different N-sulfonyl groups on the ketimines and investigates methods for modifying the dihydropyridinone structures themselves.
Article Abstract
The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael addition/lactamisation cascade gives access to a range of dihydropyridinones with high enantioselectivity. The nature of the N-sulfonyl group present on the ketimine is extensively investigated, with further studies into derivatisation of the dihydropyridinone core also reported.
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| http://dx.doi.org/10.1039/c4ob02408g | DOI Listing |
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