Dimethylsulfoniopropionate is a highly abundant sulfur metabolite in marine ecosystems. Its biosynthesis by different organisms including plants, marine algae and dinoflagellates is discussed. Furthermore, the accumulated knowledge about bacterial uptake systems and its climatically relevant degradation by marine bacteria to methanethiol or dimethylsulfide is presented. Finally, uptake and degradation of synthetic DMSP analogs are addressed.
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http://dx.doi.org/10.1039/c4ob02407a | DOI Listing |
Sci Bull (Beijing)
March 2025
State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Centre for New Organic Matter, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Centre for Analytical Sciences, College of Chemistry, School of Medicine and Frontiers Science Center for Cell Responses, Nankai University, Tianjin 300071, China. Electronic address:
ACS Nano
March 2025
Faculty of Physics, Ludwig-Maximilians University, Geschwister-Scholl-Platz 1, 80539 Munich, Germany.
Lipid nanoparticles (LNPs) are efficient and safe carriers for mRNA vaccines based on advanced ionizable lipids. It is understood that the pH-dependent structural transition of the mesoscopic LNP core phase plays a key role in mRNA transfer. However, buffer-specific variations in transfection efficiency remain obscure.
View Article and Find Full Text PDFPlant Sci
March 2025
Institute of Agrophysics, Polish Academy of Sciences, Doświadczalna 4, 20-290 Lublin, Poland. Electronic address:
Tomato fruit ripening is a complex physiological process that involves morphological, anatomical, biochemical, and molecular alterations. One of these changes occurring during ripening is the softening of the fruit, which is attributed to modifications in the biosynthesis and degradation of individual cell wall components, i.e.
View Article and Find Full Text PDFInt J Biol Macromol
March 2025
State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China. Electronic address:
Caseinolytic protease P (ClpP) protein is essential for prokaryotic and eukaryotic protein homeostasis, and has emerged as a promising bactericidal target for controlling bacterial infection and evading the emergent of drug-resistance risk. As the unique bactericidal mechanism, ClpP loses its substrate specificity and undergoes uncontrolled protein hydrolysis in the presence of an activator, leading to causing bacterial death. To further expand the chemotype of ClpP activator, a series of ONC212 derivatives were synthesized using a ring expansion strategy.
View Article and Find Full Text PDFJ Ethnopharmacol
March 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin 150040, China. Electronic address:
Unlabelled: ETHNIC PHARMACOLOGICAL RELEVANCE: "Cyathula officinalis Kuan (COK)" has the effect of "guiding the drug downward" and can enhance the efficacy of formula, e.g., Shentong Zhuyu Decoction (STZYD).
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