AI Article Synopsis
- Patients commonly show symptoms like fatigue, an enlarged spleen, and low blood cell counts (pancytopenia), but the prognosis is generally good with proper treatment options like purine analogs and interferon-alpha.
- A case of a patient with breast cancer revealed a left femoral bone lesion that was diagnosed as HCL through various techniques, highlighting the need for biopsy to ensure accurate diagnosis since HCL can respond well to treatment.
Article Abstract
Hairy cell leukemia (HCL) is an indolent neoplasm of small mature B lymphoid cells with characteristic morphologic features usually involving the peripheral blood, bone marrow, and spleen. It constitutes approximately 2% of adult leukemias and has a male predominance. Patients usually present with weakness, splenomegaly, and pancytopenia. The overall prognosis is favorable with appropriate treatment including purine analogs, interferon-alpha, and radiation. We report a patient with a history of breast cancer who presented with a left femoral lytic bone lesion that was subsequently diagnosed as HCL by morphology, immunohistochemistry, flow cytometry, and molecular genetic techniques. It was important to biopsy the lesion to establish the correct diagnosis, as HCL is a highly treatment-responsive malignancy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264715 | PMC |
| http://dx.doi.org/10.1080/08998280.2015.11929191 | DOI Listing |
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