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Lymphomas in 3D and 4D spaces.
Hum Pathol
November 2024
Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany. Electronic address:
Article Synopsis
- - The lymph node is structured into dynamic compartments like T and B zones, which enhance both innate and adaptive immune responses and have led to new insights across various biological and medical fields.
- - The review emphasizes advanced 3D and 4D imaging techniques to study human lymph nodes, highlighting the insights gained from these methods compared to traditional 2D tissue analysis, particularly in understanding immune interactions and lymphoma behavior.
- - Findings show that T cells move faster than B cells and reticulum cells within reactive lymphoid tissue, with variations in cell contact times potentially aiding in lymphoma classification; 4D technology can also play a key role in testing new cancer therapies.
The biology of classical Hodgkin lymphoma.
Semin Hematol
August 2024
Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address:
Article Synopsis
- * Core signal transduction pathways in cHL are often aberrant or constantly activated, largely due to genetic mutations that disrupt normal cellular functions.
- * Advancements in understanding cHL's biology have led to better treatments, and continued research may uncover new mechanisms that can further inform treatment options in the future.
Steady-state approximations for Hodgkin-Huxley cell models: Reduction of order for uterine smooth muscle cell model.
PLoS Comput Biol
August 2023
Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Multi-scale mathematical bioelectrical models of organs such as the uterus, stomach or heart present challenges both for accuracy and computational tractability. These multi-scale models are typically founded on models of biological cells derived from the classic Hodkgin-Huxley (HH) formalism. Ion channel behaviour is tracked with dynamical variables representing activation or inactivation of currents that relax to steady-state dependencies on cellular membrane voltage.
View Article and Find Full Text PDFClonal composition and differentiation stage of human CD30 B cells in reactive lymph nodes.
Front Immunol
August 2023
Frankfurt Institute of Advanced Studies, Frankfurt/Main, Germany.
Introduction: Normal CD30 B cells represent a distinct B-cell differentiation stage with features of strong activation. We lack an in depth understanding of these cells, because they are not present in peripheral blood and are typically very rare in reactive lymphoid organs. CD30 B cells have been discussed as a potential precursor population for the malignant CD30 Hodgkin and Reed-Sternberg cells in classical Hodgkin lymphoma.
View Article and Find Full Text PDFDigital spatial profiling of CD4 T cells in classic Hodgkin lymphoma.
Virchows Arch
August 2023
Department of Pathology, Kurume University School of Medicine, Kurume City, Fukuoka, Japan.
Classic Hodgkin lymphoma (CHL) harbors a small number of Hodgkin-Reed-Sternberg (HRS) cells scattered among numerous lymphocytes. HRS cells are surrounded by distinct CD4 T cells in a rosette-like manner. These CD4 T cell rosettes play an important role in the tumor microenvironment (TME) of CHL.
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