This review describes the reactions of o-aminothiophenol and its derivatives as building blocks for the synthesis of poly-functionalised 1,5-benzothiazepines with pharmacological interest. Annelated 1,5-benzothiazepines were prepared by acyclocondensation reaction of o-aminothiophenol and its derivatives with carbonyl and other functionalities. In case ofcarbonyl function this reaction takes place by a nucleophilic addition, followed by a cyclisation and concomitant elimi-nation of water. The objective of this survey is to provide a comprehensive account of the synthesis of various 1,5-ben-zothiazepines derivatives and their potential to develop better chemotherapeutic agents.
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Recent Advances in the Development of Greener Methodologies for the Synthesis of Benzothiazoles.
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School of Chemical Sciences, Indian Association for the Cultivation of Science (IACS), Jadavpur, Kolkata, West Bengal 700 032, India.
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Department of Chemistry, Bharathiar University, Coimbatore 641046, Tamil Nadu, India. Electronic address:
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