The one-pot four-component reaction of benzohydrazide (2-picolinohydrazide), acetylenedicarboxylate, isatins and malononitrile (ethyl cyanoacetate) with triethylamine as base catalyst afforded functionalized 1-benzamidospiro[indoline-3,4'-pyridines] in good yields. (1)H NMR spectra indicated that an equilibrium of cis/trans-conformations exist in the obtained products.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273213 | PMC |
| http://dx.doi.org/10.3762/bjoc.10.281 | DOI Listing |
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