A green approach to the synthesis of novel phytosphingolipidyl β-cyclodextrin designed to interact with membranes.

Beilstein J Org Chem

LG2A FRE-CNRS 3517 Institut de Chimie de Picardie FR CNRS 3085, SFR Condorcet, UPJV, 33 rue St Leu, 80039 Amiens, France.

Published: December 2014

This work reports the synthesis of a new family of mono-substituted amphiphilic cyclodextrins using a green methodology. Reactions using greener and safer catalysts with more environmentally friendly purification solvents were performed. Four unreported mono-substituted cyclodextrins bearing a phytosphingolipidyl chain and a fatty acid chain (C10, C12, C14 and C18) were successfully obtained with a promising yield.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273305PMC
http://dx.doi.org/10.3762/bjoc.10.278DOI Listing

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