AI Article Synopsis
- Gemcitabine is a standard treatment for pancreatic cancer, but many patients develop resistance to it, prompting research into alternative treatments.
- KML001 (sodium meta-arsenite) shows promise as an antitumor agent and was evaluated for its effect on gemcitabine's efficacy against pancreatic cancer cells.
- The combination of KML001 and gemcitabine significantly inhibited cancer cell growth, movement, and invasion, suggesting that this combined treatment could enhance chemotherapy effectiveness for pancreatic cancer.
Article Abstract
Background/aim: Gemcitabine is a drug commonly used to treat pancreatic cancer but chemoresistance to it is a common clinical issue. KML001 (sodium meta-arsenite) has demonstrated certain antitumor activity. The objective of the study was to evaluate the influence of KML001 on the anticancer activity of gemcitabine against pancreatic cancer cells.
Materials And Methods: Cell proliferation, migration, and invasion were assessed, as well as the expression of nuclear factor-kappa B (NF-κB) p65, epidermal growth factor receptor (EGFR), matrix metalloproteinase-2 (MMP2), and vascular endothelial growth factor-C (VEGFC) in pancreatic cancer cells.
Results: Treatment with a combination of KML001 and gemcitabine resulted in significant inhibition of cell proliferation, migration, and invasion, and significantly reduced EGFR and MMP2 expression compared to gemcitabine treatment-alone.
Conclusion: Combination treatment of gemcitabine and KML001 could be an effective chemotherapeutic treatment for pancreatic cancer.
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