AI Article Synopsis
- Scientists have found that certain substances, called ligands, and their receptors help human embryos develop before they implant in the womb.
- Research about this has been happening since the 1980s, and there are many potential candidates being studied.
- The article also talks about improving how embryos grow and how ready the womb is for them, which can help make pregnancies healthier.
Article Abstract
Extensive evidence suggests that soluble ligands and their receptors mediate human preimplantation embryo development and implantation. Progress in this complex area has been ongoing since the 1980s, with an ever-increasing list of candidates. This article specifically reviews evidence of soluble ligands and their receptors in the human preimplantation stage embryo and female reproductive tract. The focus will be on candidates produced by the human preimplantation embryo and those eliciting developmental responses in vitro, as well as endometrial factors related to implantation and receptivity. Pathways to clinical translation, including innovative diagnostics and other technologies, are also highlighted, drawing from this collective evidence toward facilitating joint improvements in embryo quality and endometrial receptivity. This strategy could not only benefit clinical outcomes in reproductive medicine but also provide broader insights into the peri-implantation period of human development to improve fetal and neonatal health.
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| http://dx.doi.org/10.1210/er.2014-1046 | DOI Listing |
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