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The NFATC2/Nrf2 cascade regulates spinal cord ischemia-reperfusion injury by controlling inflammation, apoptosis and oxidative stress.
Regen Ther
March 2025
Department of Neurorehabilitation, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, China.
Spinal cord ischemia/reperfusion (IR) injury (SCII) can cause major autonomic, sensory, and motor damage and loss. The upregulation of Nrf2, a primary orchestrator of the oxidative stress response, has beneficial effects in SCII. Here, we aimed to uncover a SCII-related transcription factor that is able to elevate Nrf2 expression.
View Article and Find Full Text PDFCharacterizing the antibody response to amustaline/glutathione pathogen-reduced red blood cells.
Transfusion
December 2024
Cerus Corporation, Concord, California, USA.
Background: The clinical significance of natural and treatment-emergent antibodies specific for amustaline/glutathione pathogen-reduced red blood cells (PRRBCs) is not known.
Study Design And Methods: A Phase 3, randomized clinical trial of PRRBCs (ReCePI) compared PRRBCs with conventional RBCs in cardiac or thoracic-aorta surgery. Subjects transfused during and for 7 days after surgery were screened for PRRBC-specific antibodies at baseline, 28 and 75 days post-surgery.
Melatonin attenuates responses to angiotensin II in isolated aortic rings of STZ-induced type 1-like DM rats.
Endocr Res
December 2024
Department of Biology, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq.
Background: In patients with diabetes mellitus (DM), vascular endothelial dysfunction (VED) is the main reason for impaired life expectancy. Melatonin (MEL) demonstrates wide-ranging effects across various organs and exhibits pleiotropic characteristics. The current study aims to investigate the modulatory roles of MEL vascular response to angiotensin II (Ang II) and its receptors including angiotensin type 1 receptor (AT-1 R) and angiotensin type 2 receptor (AT-2 R) in isolated thoracic aorta of non-diabetes (non-DM) and diabetes (DM) rats.
View Article and Find Full Text PDFDieulafoy's Lesion: A Rare Cause of Gastrointestinal Bleeding after Interrupted Aortic Arch Repair in an Adult.
Aorta (Stamford)
December 2024
Department of Cardiac Surgery, Wythenshawe Hospital, Manchester, United Kingdom.
Survival into adulthood in patients with an interrupted aortic arch (IAA) is exceedingly rare. A recent literature review found 25 reported cases of IAA in adults. We describe the first case of prolonged, occult, postoperative gastrointestinal bleeding as a major complication following IAA surgery.
View Article and Find Full Text PDFLingual Necrosis in the Setting of Giant Cell Arteritis.
Cureus
November 2024
Department of Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Giant cell arteritis (GCA) is a medium-to-large vessel vasculitis most commonly affecting the aortic arch and carotid branches. Lingual necrosis is a rare complication of GCA caused by lingual artery vasculitis due to ischemia. A delay in diagnosis can result in irreversible complications such as tongue amputation.
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