Background: Fluorescent carbon dots (Cdots) have attracted increasing attention due to their potential applications in sensing, catalysis, and biomedicine. Currently, intensive research has been concentrated on the synthesis and imaging-guided therapy of these benign photoluminescent materials. Meanwhile, Cdots have been explored as nonviral vector for nucleic acid or drug delivery by chemical modification on purpose.
Results: We have developed a microwave assisted one-step synthesis of Cdots with citric acid as carbon source and tryptophan (Trp) as both nitrogen source and passivation agent. The Cdots with uniform size show superior water solubility, excellent biocompatibility, and high quantum yield. Afterwards, the PEI (polyethylenimine)-adsorbed Cdots nanoparticles (Cdots@PEI) were applied to deliver Survivin siRNA into human gastric cancer cell line MGC-803. The results have confirmed the nanocarrier exhibited excellent biocompatibility and a significant increase in cellular delivery of siRNA, inducing efficient knockdown for Survivin protein to 6.1%. In addition, PEI@Cdots complexes mediated Survivin silencing, the arrested cell cycle progression in G1 phase as well as cell apoptosis was observed.
Conclusion: The Cdots-based and PEI-adsorbed complexes both as imaging agents and siRNA nanocarriers have been developed for Survivin siRNA delivery. And the results indicate that Cdots-based nanocarriers could be utilized in a broad range of siRNA delivery systems for cancer therapy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304159 | PMC |
| http://dx.doi.org/10.1186/s12951-014-0058-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CNT-anchored cellulose fluorescent nanofiber membranes as a fluorescence sensor for Cu and Cr.
Anal Methods
November 2017
Guangxi Zhuang Autonomous Region Forestry Research Institute, Nanning 530002, China.
1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped carbon nanotubes@cellulose (1,4-DHAQ-doped CNTs@CL) nanofibrous membranes have been prepared electrospinning and subsequent deacetylation in this work. They have been successfully applied for highly sensitive detection of Cu in aqueous solution. The surface area per unit mass (S/M) ratio of the nanofibrous membranes was enhanced by incorporating the CNTs into cellulose.
View Article and Find Full Text PDFNitrogen-doped waste biomass-derived carbon dots as fluorescent sensors for economical, green, rapid and sensitive detection of resveratrol in foods.
Food Chem
January 2025
School of Chemistry and Life Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, PR China; Advanced Institute of Materials Science, Changchun University of Technology, 2055 Yanan Street, Changchun 130012, PR China. Electronic address:
Resveratrol (Res), a natural antioxidant widely found in fruits, plays a crucial role in preventing various diseases. However, traditional detection methods usually rely on large amounts of toxic solvents, leading to high costs and potential health risks to researchers. In this work, an economical, green, rapid, and sensitive method for Res detection was developed using banana peel-derived nitrogen-doped carbon dots (BP-N-CDs) as fluorescent sensors.
View Article and Find Full Text PDFA novel and high-performance tumor inhibitor of La, N co-doped carbon dots for U251 and LN229 cells.
Colloids Surf B Biointerfaces
January 2025
Department of Neurosurgery, The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou 341000, China. Electronic address:
To address the medical challenges posed by glioblastoma, a novel and high-performance tumor inhibitor (La@FA-CDs) composed of folic acid and lanthanum nitrate hexahydrate, was successfully synthesized and demonstrated effectiveness in inhibiting the growth of U251 and LN299 cells. The microstructure of La@FA-CDs was extensively analyzed by FTIR, UV-Vis, XPS, TEM, AFM NMR, and nanoparticle size analyzer. The optical and electrical properties of La@FA-CDs were characterized using a fluorescence spectrometer and a zeta potential analyzer.
View Article and Find Full Text PDFMoS nanoflowers surface decorated with CuS nanorods and carbon dots for fluorescent and ultrasound imaging in cancer therapy.
Colloids Surf B Biointerfaces
January 2025
Department of Robotics and Mechatronics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea. Electronic address:
In recent years, the design of various ultrasound responsive echogenic nanomaterials offers many advantages such as deep tissue penetration, high signal intensity, colloidal stability, biocompatibility and less expensive for ultrasound-based cancer cell imaging while providing the option to monitor the progress of tumor volume during the treatment. Further, the ability of nanomaterials to combine photo-thermal therapy (PTT) and chemotherapy has opened a new avenue in the development of cancer theranostics for synergistic cancer therapy. Herein, we report MoS nanoflowers (NFs) surface decorated with CuS nanorods (NRs) and folic acid-derived carbon dots (FACDs) using cystine-polyethyleneimine (PEI) linker for PTT-chemotherapy.
View Article and Find Full Text PDFFabrication of Highly Fluorescent Nitrogen and Phosphorus Dual-Doped Carbon Dots for Selective Sensing of Rutin.
Luminescence
January 2025
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Based on nitrogen and phosphorus co-doped carbon dots (NP-CDs), a direct, quick, and selective sensing probe for fluorometric detection of rutin has been developed. Utilizing ethylene diamine tetra acetic acid (EDTA) as a carbon and nitrogen source and diammonium hydrogen phosphate (NH)HPO as a nitrogen and phosphorus source. The NP-CDs were synthesized in less than 3 min with a straightforward one-step microwave pyrolysis process with a high quantum yield (63.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!