Anogenital granulomatosis (AGG) is a rare chronic inflammatory disorder of unknown aetiology. It presents clinically with swelling of the genital or anoperineal area, with histopathological findings of noncaseating giant cell granulomas. Some cases of AGG are associated with underlying systemic disease, mainly Crohn disease. We report two patients with AGG. The first was a young man with ulcerative colitiis treated with infliximab, which also alleviated the developing symptoms of AGG. The second was a young woman who was otherwise healthy. After the introduction of complex decongestive therapy, the oedema was considerably reduced in both patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ced.12490 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intralesional corticosteroids and diathermy ablation for the management of anogenital granulomatosis: a retrospective cohort study.
Clin Exp Dermatol
September 2022
Departments of Plastic Surgery, St George's University Hospital, St George's Healthcare NHS Trust, London, UK.
Background: Anogenital granulomatosis (AGG) is a rare, chronic condition that presents as progressive inflammation and lymphoedema of the anogenital region in both male and female patients. No guidelines exist for the management of AGG. Systemic immunosuppressants are the current cornerstone of medical therapy for AGG, but results from case series with small numbers of patients have reported variable responses.
View Article and Find Full Text PDFAnogenital Crohn's Disease and Granulomatosis: A Systematic Review of Epidemiology, Clinical Manifestations, and Treatment.
J Crohns Colitis
June 2022
IBD Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Background And Aims: Metastatic Crohn's disease is an extraintestinal cutaneous manifestation characterised by non-specific inflammatory lesions anatomically separate from the gut; genital involvement is rare. We conducted a systematic review of anogenital Crohn's disease and granulomatosis, to provide a synthesis of epidemiology, clinical features, and treatment outcomes.
Methods: A systematic search of the literature was conducted via MEDLINE, EMBASE, and the Cochrane database from inception to December 1, 2020.
Vulvar Crohn disease: Diagnostic challenges and approach to therapy.
Int J Womens Dermatol
December 2020
Department of Dermatology, University of Wisconsin, School of Medicine and Public Health, Madison, WI, United States.
Crohn disease (CD) may be complicated by contiguous, metastatic, or associated inflammatory cutaneous lesions. Vulvar CD is a rare phenomenon characterized by granulomatous genital inflammation that occurs independently from fistulizing CD. Left untreated, vulvar CD can result in debilitating lymphedema, disfiguring anatomic changes, secondary abscesses, cellulitis, and squamous cell carcinoma.
View Article and Find Full Text PDFA case of vulvitis granulomatosa.
JAAD Case Rep
June 2020
Department of Dermatology, King Abdulaziz University, Jeddah, Saudi Arabia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!