AI Article Synopsis
- A study explored how body composition, particularly body mass index (BMI) and weight changes, affects survival rates in patients with head and neck cancer.
- Results indicated that higher BMI is linked to better survival; patients who were overweight or obese had significantly higher five-year survival rates compared to underweight individuals.
- Weight stability was also important, with stable weight showing the highest survival rates, while significant weight gain led to worse outcomes, emphasizing the relevance of BMI in prognosis and treatment strategies.
Article Abstract
Background: Recent evidence has suggested links between obesity and outcomes for various types of cancer. This study investigates the impact that body composition has on survival in patients with head and neck cancer.
Methods: Data prospectively collected from 578 patients were analyzed using Cox regression models to determine independent associations that pretreatment body mass index (BMI) and 3-month weight change have on observed survival.
Results: Higher BMIs were associated with better survival (p < .001). Five-year rates ranged from 33.8% for underweight to 75.3% for overweight/obese patients. Patients with stable weight had the highest 5-year rate (72.6%; p = .019), whereas patients who gained ≥5% had worse survival (45.8%) than those who lost ≥5% (65.8%). BMI independently predicted survival, whereas weight change was not an independent predictor.
Conclusion: This demonstrated association between BMI and survival provides useful information when offering prognoses and investigating optimal treatments © 2015 Wiley Periodicals, Inc. Head Neck 38: E261-E267, 2016.
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| http://dx.doi.org/10.1002/hed.23983 | DOI Listing |
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