Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2014.11.158 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structure-based identification of HNF4α agonists: Rosmarinic acid as a promising candidate for NAFLD treatment.
Comput Struct Biotechnol J
December 2024
National Vaccine Innovation Platform, Scholl of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Unlabelled: The prevention and treatment of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), have emerged as critical global health challenges. Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. Hepatocyte nuclear factor 4α (HNF4α) has been identified as a pivotal regulator of lipid metabolism, making it an attractive target for drug development.
View Article and Find Full Text PDFAMPKα2/HNF4A/BORIS/GLUT4 pathway promotes hepatocellular carcinoma cell invasion and metastasis in low glucose microenviroment.
Biochem Pharmacol
September 2022
Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu 610041, Sichuan Province, China. Electronic address:
Increasing evidence has revealed that the invasion and metastasis of HCC are intimately related to the low-glucose microenvironment, but the intrinsic regulatory mechanism remains unclear. It has been well documented that AMPK regulates the transcriptional expression of GLUT4 and its catalytic subunit AMPKα2 can negatively regulate the downstream target molecule HNF4A. Meanwhile, BORIS (Brother of the Regulator of Imprinted Sites) is able to modulate the Warburg effect by regulating the splicing of pyruvate kinase M2 (PKM2), a critical enzyme in glycolysis.
View Article and Find Full Text PDFIdentifying new drugs associated with pulmonary arterial hypertension: A WHO pharmacovigilance database disproportionality analysis.
Br J Clin Pharmacol
December 2022
Pharmacovigilance Unit, Grenoble Alpes University Hospital, Grenoble, France.
Unlabelled: Since the 1960s, several drugs have been linked to the onset or aggravation of pulmonary arterial hypertension (PAH): dasatinib, some amphetamine-like appetite suppressants (aminorex, fenfluramine, dexfenfluramine, benfluorex) and recreational drugs (methamphetamine). Moreover, in numerous cases, the implication of other drugs with PAH have been suggested, but the precise identification of iatrogenic aetiologies of PAH is challenging given the scarcity of this disease and the potential long latency period between drug intake and PAH onset. In this context, we used the World Health Organization's pharmacovigilance database, VigiBase, to generate new hypotheses about drug associated PAH.
View Article and Find Full Text PDFLiver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist.
Cell Death Dis
June 2021
SBP Medical Discovery Institute, La Jolla, CA, USA.
Article Synopsis
- Researchers discovered strong HNF4α agonists, NCT and NFT, that regulate fat storage in the liver by inducing lipophagy via dihydroceramides.
- These agonists are structurally related to weak HNF4α activators and effectively cleared fat from cells in vitro.
- In experiments with DIO mice, NCT improved liver function and reduced fat buildup, showing promise as a safe treatment for non-alcoholic fatty liver disease (NAFLD).
HNF4a transcription is a target of trichloroethylene toxicity in the embryonic mouse heart.
Environ Sci Process Impacts
March 2020
Department of Cellular and Molecular Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, Arizona 85724-5044, USA.
In exploration of congenital heart defects produced by TCE, Hepatocyte Nuclear Factor 4 alpha (HNF4a) transcriptional activity was identified as a central component. TCE exposure altered gene transcription in the chick heart in a non-monotonic pattern where only low dose exposure inhibited transcription by HNF4a. As the chick embryo is non-placental, we examine here HNF4a as a target of TCE in developing mouse embryos.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!