Recent studies demonstrated an association between the K153R polymorphism in the myostatin gene with extreme longevity, lower muscle strength and obesity but the molecular basis of these associations has not been clarified. Here, we show that the K153R mutation significantly increases the rate of proteolysis of promyostatin by furin, but has no effect on the activity of the latent complex or the cleavage of the latent complex by bone morphogenetic protein 1 (BMP-1). The increased rate of activation of K153R mutant promyostatin may explain why this polymorphism is associated with obesity, lower muscle strength and extension of lifespan.
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Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation.
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Academic Department of Physical Education, Plekhanov Russian University of Economics, Moscow 117997, Russia.
Polymorphism (rs1805086), , () of the myostatin gene () has been associated with a skeletal muscle phenotype (hypertrophic response in muscles due to strength training). However, there are not enough reliable data to demonstrate whether rs1805086 K and R allelic variants are valid genetic factors that can affect the strength phenotype of athletes' skeletal muscles. The aim is to conduct a systematic review and meta-analysis of the association of rs1805086 polymorphism with the strength phenotype of athletes.
View Article and Find Full Text PDFThe myostatin rs1805086 variant is associated with obesity in Mexican adults, independently of metabolic risk factors.
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Human Nutrition Laboratory, Department of Natural Sciences, Autonomous University of Queretaro, Campus Juriquilla, Queretaro, Mexico.
Aim: To determine whether rs1805086 is associated with obesity and metabolic disturbances in a Mexican adult population.
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Introduction: One of the genetic contributors to sarcopenia predisposition is Myostatin (MSTN), which in humans encodes myostatin, a 376 amino acid growth factor protein that negatively regulates muscle growth. The aim of this study was to investigate MSTN polymorphisms in an elderly sarcopenic population in Turkey and determine how they relate to sarcopenia.
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Meir Medical Center, Child Health and Sports Center, Pediatric Department, Sackler School of Medicine, Tel-Aviv University, Israel.
Unlabelled: The myostatin (MSTN) Lys(K)-153Arg(R) polymorphism may influence skeletal muscle phenotypes. Carrying the rare R allele was associated with greater muscle mass.
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