Background: D-lactic acidosis, also referred as D-lactate encephalopathy, has been reported in patients with short bowl syndrome (SBS).
Case Report: The neurologic symptoms include altered mental status, slurred speech, and ataxia. Onset of neurological symptoms is accompanied by metabolic acidosis and high anion gap. We present here a case of D-lactic acidosis in a patient with acute lymphoblastic leukemia (ALL) who developed severe neurological symptoms and metabolic acidosis due to vancomycin-resistant enterococci (VRE) infection, and elevated D-lactic acid.
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The D-lactate enigma: exploring the inflammatory influence of D-lactate in cattle.
Front Vet Sci
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Laboratory of Inflammation Pharmacology and Immunometabolism, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Valdivia, Chile.
D-lactic acidosis is associated with fermentative disturbances and is often marked by elevated levels of D-lactic acid in the blood, ruminal fluid, and synovial fluid in cattle. D-lactic acidosis is linked to various inflammatory manifestations, and although the causative factors have been extensively explored, the exact pathogenesis of the associated inflammation remains elusive. Notably, less attention has been given to D-lactate, a stereoisomer found in the plasma of affected animals, which may lead to D-lactic acidosis.
View Article and Find Full Text PDFMetabolic acidosis due to d-lactate in a patient with intestinal resection: Diagnostic challenges and nutritional strategies.
Int J Surg Case Rep
December 2024
Faculty of Health, Universidad Santiago de Cali, Cali, Colombia. Electronic address:
Introduction: Metabolic acidosis, marked by decreased plasma bicarbonate and arterial pH, is a common complication following extensive abdominal surgeries. D-lactate acidosis presents additional diagnostic challenges due to nonspecific symptoms.
Presentation Of Case: A 65-year-old woman with hypertension and morbid obesity was admitted to the ICU for intestinal obstruction and peritonitis due to an incarcerated hernia.
Contaminated well water driving d-lactic acidosis in child with short bowel syndrome.
JPGN Rep
November 2024
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics Nationwide Children's Hospital Columbus Ohio USA.
d-Lactic acidosis is a rare type of lactic acidosis that typically presents in patients with short bowel syndrome (SBS). Clinical features include a high anion-gap metabolic acidosis and acute onset of neurological impairment. The underlying pathology is thought to be due to altered gut flora and carbohydrate malabsorption in patients with altered gut anatomy.
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Center for Advanced Intestinal Rehabilitation, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Background: D-lactic acidosis (DLA) is a serious complication of short bowel syndrome (SBS) in children with intestinal failure (IF). Malabsorbed carbohydrates are metabolized by bacteria in the intestine to D-lactate which can lead to metabolic acidosis and neurologic symptoms.
Methods: A retrospective chart review was performed in children ≤18 years old with SBS who had one of the following criteria: unexplained metabolic acidosis, neurologic signs or symptoms, history of antibiotic therapy for small bowel bacterial overgrowth, or high clinical suspicion of DLA.
Malignancy Associated Type B Lactic Acidosis: A Rare, yet Fascinating Oncological Emergency.
R I Med J (2013)
February 2024
Chief of Hematology/Medical Oncology, Providence VAMC; Clinical Associate Professor of Medicine, Brown University, Providence, RI 02908.
Type B lactic acidosis has been described infrequently in hematologic malignancies, but even less often in solid tumors. Since 1978, there have been only 58 cases of solid tumor associated Type B lactic acidosis described in the literature. Lung cancer (neuroendocrine) is the most common tumor; others frequently have a poorly/undifferentiated histology.
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