There are currently very few test objects suitable for high-frequency ultrasound scanners that can be rapidly manufactured, have appropriate acoustic characteristics and are suitably robust. Here we describe techniques for the creation of a wall-less flow phantom using a physically robust konjac and carrageenan-based tissue-mimicking material. Vessel dimensions equivalent to those of mouse and rat arteries were achieved with steady flow, with the vessel at a depth of 1.0 mm. We then employed the phantom to briefly investigate velocity errors using pulsed wave Doppler with a commercial preclinical ultrasound system. This phantom will provide a useful tool for testing preclinical ultrasound imaging systems.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342409 | PMC |
http://dx.doi.org/10.1016/j.ultrasmedbio.2014.09.018 | DOI Listing |
Acc Chem Res
November 2024
Department of Chemistry, University of Missouri, Columbia, Missouri 65211, United States.
ConspectusThe study of gas-phase chemical reactions at very low temperatures first became possible with the development and implementation of the CRESU (French acronym for Reaction Kinetics in Uniform Supersonic Flows) technique. CRESU relies on a uniform supersonic flow produced by expansion of a gas through a Laval (convergent-divergent) nozzle to produce a wall-less reactor at temperatures from 10 to 200 K and densities of 10-10 cm for the study of low temperature kinetics, with particular application to astrochemistry. In recent years, we have combined uniform flows with revolutionary advances in broadband rotational spectroscopy to yield an instrument that affords near-universal detection for novel applications in photodissociation, reaction dynamics, and kinetics.
View Article and Find Full Text PDFIEEE Trans Ultrason Ferroelectr Freq Control
July 2024
In the development of ultrasound localization microscopy (ULM) methods, appropriate test beds are needed to facilitate algorithmic performance calibration. Here, we present the design of a new ULM-compatible microvascular phantom with a forked, V-shaped wall-less flow channel pair ( 250 μ m channel width) that is bifurcated at a separation rate of 50 μ m/mm. The lumen core was fabricated using additive manufacturing, and it was molded within a polyvinyl alcohol (PVA) tissue-mimicking slab using the lost-core casting method.
View Article and Find Full Text PDFUltrasound Med Biol
June 2024
Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Objective: Intraoperative Doppler ultrasound imaging of human brain vasculature is an emerging neuro-imaging modality that offers vascular brain mapping with unprecedented spatiotemporal resolution. At present, however, access to the human brain using Doppler Ultrasound is only possible in this intraoperative context, posing a significant challenge for validation of imaging techniques. This challenge necessitates the development of realistic flow phantoms outside of the neurosurgical operating room as external platforms for testing hardware and software.
View Article and Find Full Text PDFBioengineering (Basel)
January 2024
Laboratory of Biology and Information Science, School of Life Sciences, East China Normal University, Shanghai 200062, China.
Ultrasound Med Biol
January 2024
Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, Japan.
Objective: To evaluate and optimize high-frequency ultrasound (HFUS) imaging techniques that visualize the morphology of microscale vasculatures, many studies have used flow phantoms with straight channels. However, the previous phantoms lack the complexity of microvessels to simulate a realistic vascular environment in a shallow depth. This study was aimed at devising a new protocol for fabrication of a microflow phantom with bifurcated geometry at a superficial region.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!