Animal research has made major contributions to the health and welfare of humans and domestic animals. Immunization, first developed against rabies and anthrax by Pasteur using dogs, sheep, and rabbits, is now used to control many infectious diseases. The first drug, Salvarsan, was developed by Ehrlich using rabbits infected with the organism causing syphilis. This was the forerunner of the many drugs developed by the pharmaceutical industry today. The discovery of vitamins using rats has almost eliminated diseases such as scurvy and rickets; and hormones, such as insulin discovered following work in dogs, have helped to control many metabolic diseases. These and many other advances have enabled physicians to treat a wide range of human diseases. But many diseases continue to cause suffering.
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Evaluating the impact of modeling choices on the performance of integrated genetic and clinical models.
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Purpose: The value of genetic information for improving the performance of clinical risk prediction models has yielded variable conclusions. Many methodological decisions have the potential to contribute to differential results. We performed multiple modeling experiments integrating clinical and demographic data from electronic health records (EHR) with genetic data to understand which decisions may affect performance.
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Instituto Mexicano del Seguro Social, IMSS Hospital General de Zona Número 17, Monterrey, Nuevo León, México.
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View Article and Find Full Text PDFComparative Outcomes of a Cognitive-Behavioral Skills Building Program on the Mental Health and Healthy Behaviors of Prenursing Students.
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Author Affiliations: The Ohio State University College of Nursing, Columbus, Ohio (Dr Hoying, Mss Terry and Gray-Bauer, and Dr Melnyk); and The University of Arizona College of Nursing, Tucson, Arizona (Dr Kelly).
Background: Nursing students experience significantly more stress related diseases when compared to non-nursing students, and the state of their mental health can result in short-term increased attrition rates and increased nursing shortages.
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Purpose: To examine associations between clinical measures (self-reported and clinician-administered) and subsequent injury rates in the year after concussion return to play (RTP) among adolescent athletes.
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College of Medical Laboratory, Dalian Medical University, Dalian, 116044, People's Republic of China.
This study aims to establish a genetic risk assessment model based on a score of short tandem repeats (STRs) of polygenic inheritance. A total of 396 children and their biological parents were collected for STR genotyping. The numbers of tandem repeats of two alleles in one STR locus were assumed to be a quantitative genetic strength for disease incidence.
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