The structure of complex networks has attracted much attention in recent years. It has been noted that many real-world examples of networked systems share a set of common architectural features. This raises important questions about their origin, for example whether such network attributes reflect common design principles or constraints imposed by selectional forces that have shaped the evolution of network topology. Is it possible to place the many patterns and forms of complex networks into a common space that reveals their relations, and what are the main rules and driving forces that determine which positions in such a space are occupied by systems that have actually evolved? We suggest that these questions can be addressed by combining concepts from two currently relatively unconnected fields. One is theoretical morphology, which has conceptualized the relations between morphological traits defined by mathematical models of biological form. The second is network science, which provides numerous quantitative tools to measure and classify different patterns of local and global network architecture across disparate types of systems. Here, we explore a new theoretical concept that lies at the intersection between both fields, the 'network morphospace'. Defined by axes that represent specific network traits, each point within such a space represents a location occupied by networks that share a set of common 'morphological' characteristics related to aspects of their connectivity. Mapping a network morphospace reveals the extent to which the space is filled by existing networks, thus allowing a distinction between actual and impossible designs and highlighting the generative potential of rules and constraints that pervade the evolution of complex systems.
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http://dx.doi.org/10.1098/rsif.2014.0881 | DOI Listing |
J Exp Zool B Mol Dev Evol
December 2024
Genomics, Bioinformatics and Evolution Group, Departament de Genètica I Microbiologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
What morphologies are more likely to appear during evolution is a central question in zoology. Here we offer a novel approach to this question based on first developmental principles. We assumed that morphogenesis results from the genetic regulation of cell properties and behaviors (adhesion, contraction, etc.
View Article and Find Full Text PDFNat Comput Sci
December 2024
Montréal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Scientific discovery in connectomics relies on network null models. The prominence of network features is conventionally evaluated against null distributions estimated using randomized networks. Modern imaging technologies provide an increasingly rich array of biologically meaningful edge weights.
View Article and Find Full Text PDFArXiv
November 2024
Department of Physics, Yale University, New Haven, CT-06520, USA.
The structure and function of a protein are determined by its amino acid sequence. While random mutations change a protein's sequence, evolutionary forces shape its structural fold and biological activity. Studies have shown that neutral networks can connect a local region of sequence space by single residue mutations that preserve viability.
View Article and Find Full Text PDFbioRxiv
November 2024
Department of Physics, Yale University, New Haven, CT-06520, USA.
The structure and function of a protein are determined by its amino acid sequence. While random mutations change a protein's sequence, evolutionary forces shape its structural fold and biological activity. Studies have shown that neutral networks can connect a local region of sequence space by single residue mutations that preserve viability.
View Article and Find Full Text PDFBrain Commun
September 2024
Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives 5293, Centre National de la Recherche Scientifique (CNRS), University of Bordeaux, 33076 Bordeaux, France.
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