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γ-Aminobutyric A receptor (GABA(A)R) regulates aquaporin 4 expression in the subependymal zone: relevance to neural precursors and water exchange. | LitMetric

AI Article Synopsis

  • * Researchers found that GABA(A) receptors work together with the water channel aquaporin 4 (AQP4) in certain precursor cells, influencing AQP4 expression by reducing a specific type of phosphorylation.
  • * This relationship between GABA(A) receptors and AQP4 is crucial for regulating cell swelling and EGFR expression in neural stem cells, impacting how these cells respond to changes in their environment.

Article Abstract

Activation of γ-aminobutyric A receptors (GABA(A)Rs) in the subependymal zone (SEZ) induces hyperpolarization and osmotic swelling in precursors, thereby promoting surface expression of the epidermal growth factor receptor (EGFR) and cell cycle entry. However, the mechanisms underlying the GABAergic modulation of cell swelling are unclear. Here, we show that GABA(A)Rs colocalize with the water channel aquaporin (AQP) 4 in prominin-1 immunopositive (P(+)) precursors in the postnatal SEZ, which include neural stem cells. GABA(A)R signaling promotes AQP4 expression by decreasing serine phosphorylation associated with the water channel. The modulation of AQP4 expression by GABA(A)R signaling is key to its effect on cell swelling and EGFR expression. In addition, GABA(A)R function also affects the ability of neural precursors to swell in response to an osmotic challenge in vitro and in vivo. Thus, the regulation of AQP4 by GABA(A)Rs is involved in controlling activation of neural stem cells and water exchange dynamics in the SEZ.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326841PMC
http://dx.doi.org/10.1074/jbc.M114.618686DOI Listing

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