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Peliosis hepatis and hepatic fibrosis in a dog infected with multiple species.
J Vet Diagn Invest
January 2025
Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
A 13-y-old, spayed female dog had regenerative anemia, lymphopenia, hypoalbuminemia, and elevated hepatic biochemical parameters. Liver biopsy revealed hepatic peliosis (hepatic sinusoidal angiectasis), frequently associated with perisinusoidal fibrosis. The dog was seroreactive to antigens by indirect fluorescent antibody assays, and quantitative PCR from blood identified subsp.
View Article and Find Full Text PDFDevelopment of Multiplex Assays for the Identification of Zoonotic Species.
Pathogens
December 2024
Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
More than one-hundred species that affect animals and humans have been described, eight of which have been associated with emerging and underdiagnosed zoonoses. Most diagnostic studies in humans have used serology or molecular assays based on the 18S rRNA gene. Because the 18S rRNA gene is highly conserved, obtaining an accurate diagnosis at the species level is difficult, particularly when the amplified DNA fragment is small.
View Article and Find Full Text PDFInfection in Canada: A Retrospective Laboratory Study and Systematic Review of the Literature.
Pathogens
December 2024
Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
is a body-louse-borne bacterium. Canadian disease has been reported primarily in populations experiencing homelessness and in Indigenous communities with limited access to water. We sought to understand the epidemiology of in Canada.
View Article and Find Full Text PDFEpidemiological characteristics and genetic diversity of Bartonella species from rodents in Guangxi Zhuang autonomous region, Southwestern China.
Acta Trop
January 2025
Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan province, China; Key Laboratory of Veterinary Biotechnology of Henan Province, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China. Electronic address:
Bartonella spp. are gram-negative bacteria recognized as zoonotic pathogens of wide spectrum mammals. Rodents are recognized as a natural reservoir of pathogens, and many Bartonella species transmitted by various blood-sucking arthropods have been detected in various rodents populations.
View Article and Find Full Text PDFYield of clinical metagenomics: insights from real-world practice for tissue infections.
EBioMedicine
December 2024
Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, PR China; Zhejiang Key Laboratory of Clinical in Vitro Diagnostic Techniques, Hangzhou, 310003, PR China; Institute of Laboratory Medicine, Zhejiang University, Hangzhou, 310003, PR China. Electronic address:
Background: While metagenomic next-generation sequencing (mNGS) has been acknowledged as a valuable diagnostic tool for infections, its clinical validity and impact on patient management when using fresh tissue samples remains uncertain.
Methods: We conducted a retrospective cross-sectional study involving patients who underwent tissue mNGS at a tertiary hospital in China from February 2021 to February 2024, aiming to assess its ability to detect plausible pathogens and its clinical validity and impact.
Findings: A total of 520 mNGS results from 508 patients were analysed, detecting plausible pathogens in 302 (58.
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