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| http://dx.doi.org/10.4103/0972-5229.146296 | DOI Listing |
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Effects of Oxiris Therapy on Cytokine Elimination after a LPS Infusion-An Experimental Animal Study.
Int J Mol Sci
August 2024
Department of Anesthesiology, Medical Faculty, University Hospital Heidelberg, University Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany.
The clinical effectiveness of Oxiris, particularly in reducing cytokines, remains uncertain due to the limited data provided. This study explored and analyzed the application value of Oxiris endotoxin adsorption technology in a large animal model. Pigs received an intravenous LPS infusion.
View Article and Find Full Text PDFOutcomes of extracorporeal blood purification with oXiris® membrane in critically ill patients: A systematic review and meta-analysis.
J Crit Care
October 2024
Department of Anaesthesiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia; Department of Anaesthesiology, Universiti Malaya Medical Centre, Kuala Lumpur, Malaysia. Electronic address:
Purpose: To evaluate the efficacy of the novel oXiris® membrane in critically ill adult patients.
Methods: We systematically searched MEDLINE, EMBASE, and CENTRAL from inception to 01/06/2023 for relevant randomised controlled trials (RCTs) and non-randomised studies of intervention (NRSI). The primary outcome was overall mortality.
Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses.
Am J Vet Res
June 2024
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Objective: Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.
View Article and Find Full Text PDFBackground: The level of bacteremia in patients with sepsis and septic shock is a predictor of complications and mortality, regardless of the type of bacteria. Devices for bacteria, endotoxin and cytokines removal by adsorption have been recently developed. Thus, extracorporeal blood purification therapies have been proposed as adjunctive therapy in sepsis in combination with drugs.
View Article and Find Full Text PDFBayesian methods: a potential path forward for sepsis trials.
Crit Care
November 2023
Department of Critical Care Medicine, University of Pittsburgh, 3550 Terrace Street, 600 Scaife Hall, Pittsburgh, PA, 15261, USA.
Background: Given the success of recent platform trials for COVID-19, Bayesian statistical methods have become an option for complex, heterogenous syndromes like sepsis. However, study design will require careful consideration of how statistical power varies using Bayesian methods across different choices for how historical data are incorporated through a prior distribution and how the analysis is ultimately conducted. Our objective with the current analysis is to assess how different uses of historical data through a prior distribution, and type of analysis influence results of a proposed trial that will be analyzed using Bayesian statistical methods.
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