AI Article Synopsis
- Recent studies show that a fatty acid binding protein (FABP) in mammalian hearts can bind free fatty acids and might be affected by free radicals, but its exact function is still unclear.
- FABP was tested for its ability to scavenge harmful free radicals (superoxide anion, hydroxyl radical, and hypochlorite radical) that could occur in a heart experiencing ischemia and reperfusion.
- The findings indicate that FABP is an effective scavenger of these radicals, potentially playing an important role in protecting the heart from damage during ischemic events.
Article Abstract
Recent investigations have indicated the presence of a fatty acid binding protein (FABP) in mammalian heart. This protein binds free fatty acids and their esters with high affinity, however, its physiological role remains unknown. Since FABP constitutes a significant amount of cystolic protein, it is likely that it would be a target for free radical attack. To test this hypothesis, FABP was examined for scavenging against free radicals such as the superoxide anion (O2-), hydroxyl radical (OH.) and hypochlorite radical (OCl.) which may be present in an ischemic reperfused heart. Our results suggest that FABP scavenges O2-, OH. and OCl. as indicated by the FABP inhibition of O2- -dependent reduction of cytochrome c, OH.-dependent hydroxybenzoic acid formation and OCl.-mediated chemiluminescence response. FABP was found to be a more potent scavenger of these free radicals compared to bovine serum albumin. Furthermore, FABP was more effective in scavenging OH. than O2-, and inhibited OH. mediated lipid peroxidation process. These results indicate that FABP can scavenge free radicals which may be present in an ischemic/reperfused heart and, thus, may play a significant physiological role in the heart during ischemia and reperfusion.
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| http://dx.doi.org/10.3109/10715768909087926 | DOI Listing |
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