AI Article Synopsis
- Patients treated with clozapine experience issues with autonomic regulation and changes in heart function.
- The medication can cross the placenta, potentially affecting the fetal heart rate.
- A reported case showed reduced fetal heart rate variability in a clozapine-treated pregnant patient, but this resolved with fetal growth and did not harm the fetus.
Article Abstract
Patients treated with clozapine show autonomic dysregulation and cardiac repolarisation changes. As clozapine crosses the placenta, it could have an impact on the fetus heart rate. We reported a case of reduction of the fetal heart rate variability in a patient treated with clozapine during her pregnancy. This anomaly disappeared with fetal maturation and it did not jeopardize the fetal well-being. This side effect had already been described and pharmacologists and obstetricians should be aware that clozapine may be responsible for these fetal heart rate alterations.
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| http://dx.doi.org/10.2515/therapie/2014214 | DOI Listing |
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