Nanoemulsions were produced by high speed stirring using an ART MICCRA D27 rotor-stator system. Nanoemulsions with a droplet size of 135 nm and a narrow size distribution were obtained. The emulsions are physically stable for at least three months. Optimized production parameters are a stirring speed of 36,000 rpm (maximum speed) and a production time of 5 min. A further reduction in processing time might be possible with a rotor with ultrafine slit size, i.e., 0.5 mm. The droplet size of the emulsion produced by high speed stirring is slightly larger than droplet sizes obtained by high pressure homogenization. However, the differences in size can be expected to have no influence on the in vivo efficacy of the emulsions. Thus, high speed stirring was found to be a highly effective method for the production of nanoemulsions. The process is fast, cost-effective and can be used for large scale production.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpharm.2014.12.040 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
All-Optical Single-Channel Plasmonic Logic Gates.
Nano Lett
January 2025
State Key Laboratory for Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.
Optical computing, renowned for its light-speed processing and low power consumption, typically relies on the coherent control of two light sources. However, there are challenges in stabilizing and maintaining high optical spatiotemporal coherence, especially for large-scale computing systems. The coherence requires rigorous feedback circuits and numerous phase shifters, introducing system instability and complexity.
View Article and Find Full Text PDFWhat Is the Mechanism by which the Introduction of Amorphous SeO Effectively Promotes Urea-Assisted Water Electrolysis Performance of Ni(OH)?
Small
January 2025
College of Materials Science and Engineering, Sichuan University, Chengdu, 610065, P. R. China.
Nickel hydroxide (Ni(OH)) is considered to be one of the most promising electrocatalysts for urea oxidation reaction (UOR) under alkaline conditions due to its flexible structure, wide composition and abundant 3D electrons. However, its slow electrochemical reaction rate, high affinity for the reaction intermediate *COOH, easy exposure to low exponential crystal faces and limited metal active sites that seriously hinder the further improvement of UOR activities. Herein it is reported electrocatalyst composed of rich oxygen-vacancy (O) defects with amorphous SeO-covered Ni(OH) (O-SeO/Ni(OH)).
View Article and Find Full Text PDFHigh Gain, Low Voltage Solar-Blind Deep UV Photodetector Based on GaO/(AlGa)O/GaN nBp Heterojunction.
Small
January 2025
Key Laboratory of UV Light Emitting Materials and Technology, Ministry of Education, Northeast Normal University, Changchun, 130024, China.
In this study an (AlGa)O barrier layer is inserted between β-GaO and GaN in a p-GaN/n-GaO diode photodetector, causing the dark current to decrease considerably, and device performance to improve significantly. The β-GaO/β-(AlGa)O/GaN n-type/Barrier/p-type photodetector achieves a photocurrent gain of 1246, responsivity of 237 A W, and specific detectivity of 5.23 × 10 cm Hz W under a bias of -20 V.
View Article and Find Full Text PDFCumulative blood pressure load and cognitive decline in older adults: An observational analysis of two large cohorts.
Cereb Circ Cogn Behav
December 2024
The George Institute for Global Health, Sydney, Australia.
Introduction: Cumulative blood pressure metrics may provide greater precision for measuring temporal risk exposure, especially in later life where data are mixed regarding associations of high blood pressure (BP) on cognitive function. We examined the relationship between greater cumulative exposure to high BP in later life and several domains of cognitive function.
Methods: Individual cognitive assessment scores and BP measurements in older adults (age ≥70 years) at baseline and over approximately 8 years of follow-up were available in the population-based Canadian Victoria Longitudinal Study (VLS) and Swedish Gothenburg H70 Birth Cohort Studies (H70).
Effect of frame foundation geometry on the dynamic response of high-speed turbo machine foundations.
Heliyon
January 2025
Civil Engineering Department, University of Technology, Baghdad, Iraq.
The foundation of the turbo-generator comprises a generator, turbine, and associated equipment situated on the top of the frame foundation, which consists of a bottom raft, top deck, and columns. The current study examines how the geometrical characteristics of the frame foundation, such as slab thickness, column dimensions, and length, affect the dynamic displacement response and the natural frequencies of the frame foundation. The work is done through 3-D dynamic modal and harmonic analyses using Ansys Workbench finite element software.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!