Treponema pallidum PCR (Tp-PCR) has been noted as a valid method for diagnosing syphilis. We compared Tp-PCR to a combination of darkfield microscopy (DFM), the reference method, and serologic testing in a cohort of 273 patients from France and Switzerland and found the diagnostic accuracy of Tp-PCR was higher than that for DFM.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285282PMC
http://dx.doi.org/10.3201/eid2101.140790DOI Listing

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