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Categorization processes in emotion expression recognition: The roles of language and essentialism.
Emotion
January 2025
Department of Psychology, University of New Hampshire.
We examined categorical processing biases in the perception and recognition of facial expressions of emotion across two studies. In both studies, participants first learned to discriminate between two ambiguous facial expressions of emotion selected from the middle of a continuous array of blended expressions (i.e.
View Article and Find Full Text PDFTherapeutic effects of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content.
Front Immunol
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United States.
Introduction: Extracellular vesicles (EVs) can potently inhibit inflammation yet there is a lack of understanding about the impact of donor characteristics on the efficacy of EVs. The goal of this study was to determine whether the sex and age of donor platelet-derived EVs (PEV) affected their ability to inhibit viral myocarditis.
Methods: PEV, isolated from men and women of all ages, was compared to PEV obtained from women under 50 years of age, which we termed premenopausal PEV (pmPEV).
cGAS-STING signaling pathway in lung cancer: Regulation on antitumor immunity and application in immunotherapy.
Chin Med J Pulm Crit Care Med
December 2024
Department of Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China.
The innate immune system has a primary role in defending against external threats, encompassing viruses, bacteria, and fungi, thereby playing a pivotal role in establishing robust protection. Recent investigations have shed light on its importance in the progression of tumors, with a particular emphasis on lung cancer. Among the various signaling pathways implicated in this intricate process, the cGAS-STING pathway emerges as a significant participant.
View Article and Find Full Text PDFGut microbiota: a novel target for exercise-mediated regulation of NLRP3 inflammasome activation.
Front Microbiol
January 2025
School of Art of Wuhan Sports University, Wuhan, China.
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition receptor in the innate immune system. Its overactivation leads to the production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute to the development and progression of various diseases. In recent years, evidence has shown that gut microbiota plays an important role in regulating the activation of NLRP3 inflammasome.
View Article and Find Full Text PDFA virus-inspired RNA mimicry approach for effective cancer immunotherapy.
J Mater Chem B
January 2025
Department of Chemical Engineering, University of Seoul, Republic of Korea.
Current cancer treatments, including chemotherapy, surgery, and radiation, often present significant challenges such as severe side effects, drug resistance, and damage to healthy tissues. To address these issues, we introduce a virus-inspired RNA mimicry approach, specifically through the development of uridine-rich nanoparticles (UNPs) synthesized using the rolling circle transcription (RCT) technique. These UNPs are designed to mimic the poly-U tail sequences of viral RNA, effectively engaging RIG-I-like receptors (RLRs) such as MDA5 and LGP2 in cancer cells.
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