AI Article Synopsis
- - Genetic studies reveal that susceptibility to esophageal cancer (EC) in families from Xin-an and Xin-xiang counties, China, is significant and contributes to the disease's high incidence.
- - Analysis of 79 EC families found a heritability rate of 67% among first-degree relatives, suggesting a strong genetic component to the disease.
- - The research indicates an additive genetic model for EC, advocating for further investigation into the specific genes linked to susceptibility in high-risk populations.
Article Abstract
Genetic epidemiological studies have shown that genetic susceptibility to esophageal cancer (EC) is an important cause of its high incidence within families in some areas of China. The purpose of this study was to obtain evidence of a genetic basis of EC in Xin-an and Xin-xiang counties in China. Familial aggregation and complex segregation analyses were performed of 79 EC families in these counties. The heritability of EC was examined using Falconer's method and complex segregation analysis was conducted with the SEGREG program in Statistical Analysis for Genetic Epidemiology (SAGE version 5.3.1). The results showed that the distribution of EC in families did not fit well into a binomial distribution. The heritability of EC among first-degree and second- degree relatives was 67.0±7.31% and 43.1%±9.80%, respectively, and the summing up powered heritability was 53.2±6.74%. The segregation ratio was 0.045. Complex segregation analysis showed that the genetic model of EC was additive. The current results provide evidence for an inherited propensity to EC in certain high-risk groups in China, and support efforts to identify the genes that confer susceptibility to this disease.
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| http://dx.doi.org/10.7314/apjcp.2014.15.22.9859 | DOI Listing |
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