We tested two hypotheses. 1) SkQ1 positively affects postnatal development of hamsters in litters born to parents receiving long-term SkQ1 treatment. 2) SkQ1 accelerates maturation of juvenile females receiving the antioxidant treatment from 10 days of age. Parental pairs were kept in an outdoor vivarium under conditions close to natural. At the age of 25 days, juvenile males in litters born to parents treated daily with SkQ1 (50 nmol/kg per os) had higher epididymis mass. Both the size of a litter and SkQ1 affected epididymis mass in young males. Both the litter size and SkQ1 affected uterus mass in 25-day-old females. Juvenile females who received SkQ1 treatment from 10 days of age demonstrated earlier opening of the vagina. This experiment was replicated with the same result. At the age of 2.5 months, virgin females treated with SkQ1 from the early age demonstrated higher ovary mass.

Download full-text PDF

Source
http://dx.doi.org/10.1134/S0006297914100125DOI Listing

Publication Analysis

Top Keywords

skq1
9
skq1 accelerates
8
accelerates maturation
8
litters born
8
born parents
8
skq1 treatment
8
juvenile females
8
treatment days
8
days age
8
epididymis mass
8

Similar Publications

Article Synopsis
  • Hypoxic tumors resist radiation due to low oxygen levels, which reduces the effectiveness of therapy; increasing oxygenation during treatment could enhance radiosensitivity.
  • Historical approaches to boost oxygen delivery to tumors have had limited success, but inhibiting cancer cell respiration may yield better results.
  • Research shows that the mitochondria-targeted antioxidant MitoQ can effectively radiosensitize breast tumors in mice, suggesting potential for its use alongside radiotherapy in clinical settings.
View Article and Find Full Text PDF

Mitochondrial aspartate aminotransferase (GOT2) protein as a potential cryodamage biomarker in rooster spermatozoa cryopreservation.

Poult Sci

December 2024

State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

Spermatozoa cryopreservation has been widely used for animal genetic conservation. Despite advances in chicken semen cryopreservation, the mechanism of spermatozoa cryodamage remains to be revealed. The cryopreservation process induces motion parameter decreased, structure damaged, proteomic and antioxidant system remodeled in spermatozoa.

View Article and Find Full Text PDF

Autoimmune uveitis is a relapsing blind-causing ocular condition with complex pathogenesis that is not completely understood. There is a high demand for accurate animal models of experimental autoimmune uveitis (EAU) suitable for elucidating the molecular mechanisms of the disease and testing new therapeutic approaches. Here, we demonstrated that photoreceptor Ca/Zn-sensor protein recoverin is a uveoretinal antigen in albino rabbits provoking typical autoimmune chorioretinitis 2-4 weeks after immunization.

View Article and Find Full Text PDF

Cancer cachexia, and the related loss of muscle and strength, worsens quality of life and lowers overall survival. Recently, a novel 'pre-atrophy' muscle weakness was identified during early-stage cancer. While mitochondrial stress responses are associated with early-stage pre-atrophy weakness, a causal relationship has not been established.

View Article and Find Full Text PDF

PM dysregulates epithelial barrier function in human corneal epithelial cells that is restored by antioxidant SKQ1.

Toxicol Appl Pharmacol

November 2024

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, School of Medicine, Detroit, MI 48201, USA. Electronic address:

Article Synopsis
  • Exposure to airborne particulate matter less than 10 μm (PM) negatively impacts the barrier integrity of the corneal epithelial cells, leading to reduced protection against environmental pollutants.
  • In experiments, both human corneal epithelial cells and mouse models showed that PM exposure decreased important proteins involved in maintaining cell junctions, compromising the overall strength of the corneal epithelial barrier.
  • The antioxidant SKQ1 was found to effectively restore the integrity of the epithelial barrier, suggesting that it may be important in preventing eye disorders caused by PM exposure.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!