We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284651 | PMC |
| http://dx.doi.org/10.1021/ol503303w | DOI Listing |
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