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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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File: /var/www/html/application/controllers/Detail.php
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File: /var/www/html/index.php
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Message: Trying to access array offset on value of type null
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Cilia are microtubule-based organelles that are present on most cells and are required for normal tissue development and function. Defective cilia cause complex syndromes with multiple organ manifestations termed ciliopathies. A crucial step during ciliogenesis in multiciliated cells (MCCs) is the association of future basal bodies with the apical plasma membrane, followed by their correct spacing and planar orientation. Here, we report a novel role for ELMO-DOCK1, which is a bipartite guanine nucleotide exchange factor complex for the small GTPase Rac1, and for the membrane-cytoskeletal linker Ezrin, in regulating centriole/basal body migration, docking and spacing. Downregulation of each component results in ciliopathy-related phenotypes in zebrafish and disrupted ciliogenesis in Xenopus epidermal MCCs. Subcellular analysis revealed a striking impairment of basal body docking and spacing, which is likely to account for the observed phenotypes. These results are substantiated by showing a genetic interaction between elmo1 and ezrin b. Finally, we provide biochemical evidence that the ELMO-DOCK1-Rac1 complex influences Ezrin phosphorylation and thereby probably serves as an important molecular switch. Collectively, we demonstrate that the ELMO-Ezrin complex orchestrates ciliary basal body migration, docking and positioning in vivo.
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http://dx.doi.org/10.1242/dev.112250 | DOI Listing |
Probiotics Antimicrob Proteins
December 2024
Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing, 210095, China.
This study aimed to investigate the effect of a multi-strain probiotic (Bifidobacterium B8101, Lactobacillus L8603, Saccharomyces bayanus S9308, Enterococcus SF9301), betaine, and their combination on intestinal epithelial development and growth performance in broilers. A total of 2800 one-day-old Ross 308 chickens were randomly divided into four groups: control (Ctrl) fed with a basal diet, multi-strain probiotic (Pb) group fed with basal diet + 100 mg/day/bird probiotic (1-14 d), betaine (Bet) fed with basal diet + 0.1% betaine (1-35 d), and a combination (Pb&Bet) fed with both probiotics and betaine.
View Article and Find Full Text PDFJ Anim Sci
December 2024
Department of Animal Sciences, University of Illinois, Urbana, Illinois, USA.
Choline is vital in a variety of physiological processes that influence brain development, growth, and carcass characteristics in birds and mammals. In this study, we investigated the influence of graded supplemental choline chloride on growth performance, carcass quality, and liver characteristics in grow-finish pigs. Pigs (672 barrows and 588 gilts) were obtained from a commercial nursery facility at 8 weeks of age and assigned to treatment based on body weight and sex, with 21 same-sex pigs comprising a replicate pen.
View Article and Find Full Text PDFZool Stud
September 2024
Biodiversity Research Center, Academia Sinica, Taipei 115, Taiwan. E-mail: (Tang).
Rützler & Muzik, 1993 is a poriferan species that competes with corals and is known as a coral-killing sponge. However, limited information is available on its biology, including morphological traits. This study aims to examine the arrangement and development of spicules in various body parts of the sponge, including settled larvae.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Wenzhou Key Laboratory for the Diagnosis and Prevention of Diabetic Complications, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Ruian, China.
Background: Fibrosis is key in the development and progression of diabetic kidney disease (DKD). Baicalin (BA), wogonin (WGN), and wogonoside (WGS) have renoprotective effects. The mechanism of alleviation of DKD progression, by improving renal fibrosis, is unclear.
View Article and Find Full Text PDFFront Neurosci
December 2024
Brain, Body and Cognition Research Group, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Elsene, Belgium.
Background: Implicit motor sequence learning (IMSL) is a cognitive function that allows us to execute multiple movements in a specific sequential order and plays a crucial role in our daily functional activities. Although the role of the basal ganglia network in IMSL is well-established, the exact involvement of the cerebellar network is less clear.
Aim: Here, we aimed to address this issue by investigating the effects of cerebellar transcranial direct-current stimulation (tDCS) on IMSL.
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