A series of nonsteroidal "dissociated" glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound ( R )-39.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265816 | PMC |
| http://dx.doi.org/10.1021/ml500387y | DOI Listing |
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