AI Article Synopsis
- This study examined how high-intensity focused ultrasound (HIFU) affects cardiac cellular function by measuring changes in electrophysiological properties and temperature in rabbit hearts.
- Significant reductions in action potential amplitude (APA) and action potential duration (APD50) were observed with increasing temperatures, with APD50 being more sensitive to changes.
- Irreversible damage occurred when temperatures exceeded 52.3°C and specific thermal dose thresholds, whereas changes were reversible at lower temperatures, indicating a critical relationship between HIFU application and tissue viability.
Article Abstract
To gain better understanding of the detailed mechanisms of high-intensity focused ultrasound (HIFU) ablation for cardiac arrhythmias, we investigated how the cellular electrophysiological (EP) changes were correlated with temperature increases and thermal dose (cumulative equivalent minutes [CEM43]) during HIFU application using Langendorff-perfused rabbit hearts. Employing voltage-sensitive dye di-4-ANEPPS, we measured the EP and temperature during HIFU using simultaneous optical mapping and infrared imaging. Both action potential amplitude (APA) and action potential duration at 50% repolarization (APD50) decreased with temperature increases, and APD50 was more thermally sensitive than APA. EP and tissue changes were irreversible when HIFU-induced temperature increased above 52.3 ± 1.4°C and log10(CEM43) above 2.16 ± 0.51 (n = 5), but were reversible when temperature was below 50.1 ± 0.8°C and log10(CEM43) below -0.9 ± 0.3 (n = 9). EP and temperature/thermal dose changes were spatially correlated with HIFU-induced tissue necrosis surrounded by a transition zone.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297512 | PMC |
| http://dx.doi.org/10.1016/j.ultrasmedbio.2014.09.009 | DOI Listing |
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