We describe the synthesis and stability analysis of novel boratriazaroles that can be viewed as bioisosteres of imidazoles or pyrazoles. These heterocycles could conveniently be obtained by condensing a boronic acid and amidrazone 1 in various solvents. A detailed stability analysis of selected compounds at different pH values as a function of time led to the identification of steric hindrance around the boron atom as a key element for stabilization.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol5032552 | DOI Listing |
Publication Analysis
Top Keywords
synthesis stability
8
stability analysis
8
stability boratriazaroles
4
boratriazaroles describe
4
describe synthesis
4
analysis novel
4
novel boratriazaroles
4
boratriazaroles viewed
4
viewed bioisosteres
4
bioisosteres imidazoles
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!