The spread of carbapenem-resistant gram negatives is a global emergency, and surveillance of new resistant clones is critical from both public health and clinical standpoints. Herein, we describe the emergence of a KPC-3-producing Escherichia coli ST69 as a cause of bloodstream infection in two Italian patients.
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Molecular characteristics and pathogenic mechanisms of KPC-3 producing hypervirulent carbapenem-resistant (ST23-K1).
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Department of Clinical Laboratory, The Affiliated Li Huili Hospital, Ningbo University, Ningbo, China.
Objective: This study aimed to comprehensively investigate hypervirulent carbapenem-resistant (CR-hvKP) in the Ningbo region. Importantly, we sought to elucidate its molecular characteristics and pathogenic mechanisms. This information will provide evidence-based insights for preventing and controlling nosocomial infections and facilitate improved clinical diagnosis and treatment in this region.
View Article and Find Full Text PDFevolution to hypermucoviscosity and ceftazidime/avibactam resistance in a liver abscess caused by sequence type 512.
mSphere
September 2024
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Article Synopsis
- Carbapenemase-producing bacteria, particularly KPC-3-producing sequence type (ST) 512, pose a significant global health threat, with increasing resistance to advanced treatments like ceftazidime/avibactam (CZA).
- This study analyzed three isolates from a single patient over 78 days, including two that originated from a liver abscess, focusing on their antimicrobial resistance and genetic characteristics.
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Genomic and epidemiological insight of an outbreak of carbapenemase-producing Enterobacterales in a Portuguese hospital with the emergence of the new KPC-124.
J Infect Public Health
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National Reference Laboratory of Antibiotic Resistance and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal; Centre for the Studies of Animal Science, Institute of Agrarian and Agri-Food Sciences and Technologies, University of Porto, Porto, Portugal; AL4AnimalS, Associate Laboratory for Animal and Veterinary Sciences, Portugal. Electronic address:
Article Synopsis
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Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid.
Ann Clin Microbiol Antimicrob
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Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Background: Despite the global prevalence of Klebsiella pneumoniae Carbapenemase (KPC)-type class A β-lactamases, occurrences of KPC-3-producing isolates in China remain infrequent. This study aims to explore the emergence, antibiotic resistance profiles, and plasmid characteristics of bla-carrying Pseudomonas aeruginosa.
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Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal.
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains are of particular concern, especially strains with mobilizable carbapenemase genes such as blaKPC, blaNDM or blaOXA-48, given that carbapenems are usually the last line drugs in the β-lactam class and, resistance to this sub-class is associated with increased mortality and frequently co-occurs with resistance to other antimicrobial classes.
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