[The manifestation of synergy during simultaneous thermochemical action on yeast cells].

In order to obtain new fundamental knowledge, patterns of manifestation of synergy have been studied after simultaneous combined action of hyperthermia (47.5-60 degrees C) with anti-tumor agents (cyclophosphamide, cisplatin) on the survival of yeast cells. To calculate the efficiency of the synergistic interaction, the dependence of cell survival on the duration of exposure at separate and simultaneous action of chemical agents and hyperthermia was used. We have found that there is a certain temperature range within which there is a synergistic enhancement of anticancer drugs and high temperature effects. Any deviation from the optimum values of the temperature results in a decrease in synergy. The possible mechanism of the revealed patterns is discussed.