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Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.
ACS Nano
January 2025
School of Medicine, Nankai University, Tianjin 300071, China.
Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.
View Article and Find Full Text PDFDasatinib and Quercetin Limit Gingival Senescence, Inflammation, and Bone Loss.
J Dent Res
January 2025
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cellular senescence has emerged as one of the central hallmarks of aging and drivers of chronic comorbidities, including periodontal diseases. Senescence can also occur in younger tissues and instigate metabolic alterations and dysfunction, culminating in accelerated aging and pathological consequences. Senotherapeutics, such as the combination of dasatinib and quercetin (DQ), are being increasingly used to improve the clinical outcomes of chronic disorders and promote a healthy life span through the reduction of senescent cell burden and senescence-associated secretory phenotype (SASP).
View Article and Find Full Text PDFAn Innovative Linear Wireless Sensor Network Reliability Evaluation Algorithm.
Sensors (Basel)
January 2025
College of Information Science and Engineering, Shenyang University of Technology, Shenyang 110167, China.
In recent years, wireless sensor networks (WSNs) have become a crucial technology for infrastructure monitoring. To ensure the reliability of monitoring services, evaluating the network's reliability is particularly important. Sensor nodes are distributed linearly when monitoring linear structures, such as railway bridges, forming what is known as a Linear Wireless Sensor Network (LWSN).
View Article and Find Full Text PDFIssues and Limitations on the Road to Fair and Inclusive AI Solutions for Biomedical Challenges.
Sensors (Basel)
January 2025
School of Mathematics, Physics and Computing, University of Southern Queensland, Springfield, QLD 4300, Australia.
Objective: In this paper, we explore the correlation between performance reporting and the development of inclusive AI solutions for biomedical problems. Our study examines the critical aspects of bias and noise in the context of medical decision support, aiming to provide actionable solutions. Contributions: A key contribution of our work is the recognition that measurement processes introduce noise and bias arising from human data interpretation and selection.
View Article and Find Full Text PDFAutomatic Parking Trajectory Planning Based on Warm Start Nonlinear Dynamic Optimization.
Sensors (Basel)
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Xi'an Aerospace Chemical Propulsion Co., Ltd., Xi'an 710089, China.
In this paper, we propose an optimal parking path planning method based on numerical solving, which leverages the concept of the distance between convex sets. The obstacle avoidance constraints were transformed into continuous, smooth nonlinear constraints using the Lagrange dual function. This approach enables the determination of a globally optimal parking path while satisfying vehicular kinematic constraints.
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