AI Article Synopsis
- Telomeric DNA is identified as a promising target for new anticancer drugs, using a copper-acridine-ATCUN complex (CuGGHK-Acr) that specifically interacts with G-quadruplex structures.
- Experimental methods like fluorescence assays and gel sequencing confirm that CuGGHK-Acr effectively binds to and cleaves the G-quadruplex telomere sequence.
- The compound significantly inhibits cancer cell growth and shortens telomeres, leading to cellular aging (senescence) and programmed cell death (apoptosis) in breast cancer cells (MCF7).
Article Abstract
Telomeric DNA represents a novel target for the development of anticancer drugs. By application of a catalytic metallodrug strategy, a copper-acridine-ATCUN complex (CuGGHK-Acr) has been designed that targets G-quadruplex telomeric DNA. Both fluorescence solution assays and gel sequencing demonstrate the CuGGHK-Acr catalyst to selectively bind and cleave the G-quadruplex telomere sequence. The cleavage pathway has been mapped by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) experiments. CuGGHK-Acr promotes significant inhibition of cancer cell proliferation and shortening of telomere length. Both senescence and apoptosis are induced in the breast cancer cell line MCF7.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522906 | PMC |
| http://dx.doi.org/10.1002/anie.201410434 | DOI Listing |
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