Menzerath's law, the tendency of Z (the mean size of the parts) to decrease as X (the number of parts) increases, is found in language, music and genomes. Recently, it has been argued that the presence of the law in genomes is an inevitable consequence of the fact that Z=Y/X, which would imply that Z scales with X as Z ∼ 1/X. That scaling is a very particular case of Menzerath-Altmann law that has been rejected by means of a correlation test between X and Y in genomes, being X the number of chromosomes of a species, Y its genome size in bases and Z the mean chromosome size. Here we review the statistical foundations of that test and consider three non-parametric tests based upon different correlation metrics and one parametric test to evaluate if Z ∼ 1/X in genomes. The most powerful test is a new non-parametric one based upon the correlation ratio, which is able to reject Z ∼ 1/X in nine out of 11 taxonomic groups and detect a borderline group. Rather than a fact, Z ∼ 1/X is a baseline that real genomes do not meet. The view of Menzerath-Altmann law as inevitable is seriously flawed.
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http://dx.doi.org/10.1515/sagmb-2013-0034 | DOI Listing |
Nat Commun
August 2021
Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collection comprises 59 tumors collected from 30 patients between 2012-2020, coinciding with availability of abiraterone and enzalutamide.
View Article and Find Full Text PDFClin Sci (Lond)
July 2019
Institut de Recerca del Hospital de la Santa Creu i Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain
Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical management of AAA is limited to surgical repair, while an effective pharmacotherapy is still awaited. Endoplasmic reticulum (ER) stress and mitochondrial dysfunction have been involved in the pathogenesis of cardiovascular diseases (CVDs), although their contribution to AAA development is uncertain.
View Article and Find Full Text PDFR Soc Open Sci
January 2019
School of Chemistry and Chemical Engineering, Northeast Petroleum University, No. 199 Fazhan Road, High-tech Development Zone, Daqing 163318, People's Republic of China.
In the paper, the isomorphous doped KFeO, aimed at the remediation of the discharge and stability of the super-iron battery, was first synthesized for doping and reforming the KFeO crystalline structure via a facile co-precipitation and mechanochemistry. Afterwards, the compared cathodes were assembled by the undoped and doped KFeO for an evaluation of the discharge and stability in the AAA super-iron battery system. The results show that the small amounts of KSO were doped into the KFeO in the calculated form of KFeSO by the isomorphous substitution.
View Article and Find Full Text PDFJ Phys Chem B
April 2018
Department of Chemistry , Tufts University, Medford , Massachusetts 02155 , United States.
Cyclic peptides are a promising class of molecules for unique applications. Unfortunately, cyclic peptide design is severely limited by the difficulty in predicting the conformations they will adopt in solution. In this work, we use explicit-solvent molecular dynamics simulations to design well-structured cyclic peptides by studying their sequence-structure relationships.
View Article and Find Full Text PDFBMC Surg
May 2013
Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University, via Pansini 5, 80131 Naples, Italy.
Background: Abdominal aortic aneurysm (AAA) is a frequent cause of death among elderly. Patients affected by lower extremity peripheral arterial disease (LE-PAD) seem to be particularly at high risk for AAA. We aimed this study at assessing the prevalence and the clinical predictors of the presence of AAA in a homogeneous cohort of LE-PAD patients affected by intermittent claudication.
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