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Natriuretic peptide interaction with [3H]isatin binding sites in rat brain.
Brain Res
May 2005
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogodinskaya Str., 19992 Moscow, Russia.
Isatin is an endogenous indole, which has a distinct and discontinuous distribution in the brain and exhibits a wide range of physiological and pharmacological effects. In the present study, we have demonstrated that atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) inhibited [3H]isatin binding to rat brain sections and isolated membrane fractions. Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling.
View Article and Find Full Text PDFMy fifty years (almost) of monoamine oxidase.
Neurotoxicology
January 2004
Institute of Reproductive and Developmental Biology, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
Tyramine conjugation deficit in patients with chronic idiopathic temporomandibular joint and orofacial pain.
Pain
August 1993
Joint Department of Maxillofacial Surgery and Oral Medicine, Eastman Dental and University College Hospitals, London WC1X 8LD UK Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London W6 OXG UK.
This study was carried out to explore the value of the tyramine conjugation test, an established trait marker for 'endogenous unipolar depression', in patients with chronic idiopathic temporomandibular joint and orofacial pain. Our results show that the pain patients excrete significantly lower amounts of tyramine sulphate than controls (P < 0.0004).
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