Objectives: Malignant myoepithelioma of salivary glands is a rare neoplasm; most arise in the parotid gland and minor salivary glands of the palate. Surgery has been the mainstay of treatment.
Methods: This is case report of a patient treated with primary radical radiotherapy and retrospective review of institutional experience.
Results: An 87-year-old man with locoregionally advanced malignant myoepithelioma of the parotid gland received radiotherapy alone with complete clinical response and sustained 39 months of posttreatment. Between 1981 and 2012, 15 cases of malignant myoepithelioma of the parotid were seen. Thirteen patients received surgical excision and adjuvant radiotherapy. At a median follow-up of 47 months, 12 patients were alive without recurrence, 2 died without recurrence, and 1 died with metastatic myoepithelioma.
Conclusions: Durable locoregional disease control and disease-free-survival was achieved in the majority of patients. The case reported suggests radiation therapy may be an effective treatment option for inoperable cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/COC.0000000000000155 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clear cell myoepithelioma of palate: A rare case report with brief review of literature.
J Oral Maxillofac Pathol
October 2024
Department of Pathology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y.Patil Vidyapeeth, Pune, Maharashtra, India.
Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology.
View Article and Find Full Text PDFReappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms.
Virchows Arch
December 2024
Department of Pathology, MS 250, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN, 38105, USA.
Soft tissue myoepithelial tumors (METs) are diagnostically challenging tumors that require careful histologic and immunohistochemical characterization for accurate classification. Nearly half of METs show recurrent EWSR1 or FUS gene rearrangements with a diverse set of fusion partners. The diversity of fusion partners and lack of known driver abnormalities in many cases raises the question of whether METs represent a uniformly distinct tumor entity.
View Article and Find Full Text PDFADENOMYOEPITHELIOMA WITH CARCINOMA; EPITHELIAL-MYOEPITHELIAL CARCINOMA WITH EARLY PULMONARY METASTASIS.
J Ayub Med Coll Abbottabad
December 2024
Armed forces institute of Pathology, Rawalpindi-Pakistan.
Adenomyoepithelioma (AME) is a rare variant of breast neoplasm. It is a biphasic tumour characterized by small epithelial-lined spaces with inner luminal cells and outer of abluminal (myoepithelial) cells. Either - or both - of these two cells may rarely undergo malignant transformation.
View Article and Find Full Text PDFPrimary intracranial myoepithelioma in a child.
Childs Nerv Syst
November 2024
Department of Neurosurgery, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Myoepitheliomal tumours, associated with the salivary glands and certain soft tissue sites, are unusually encountered in the central nervous system (CNS). In the brain, although the most common location is the Sella, other areas can infrequently be involved. Such intracranial lesions are exceptionally rare in children.
View Article and Find Full Text PDFClinical Features and Prognosis of Primary Epithelial-Myoepithelial Carcinoma of Salivary Gland: A Surveillance, Epidemiology, and End Results Database-Based Study.
Cancer Control
November 2024
Shanda North Road Branch, Jinan Stomatological Hospital, Jinan, People's Republic of China.
Objective: The clinical characteristics and prognosis of primary epithelial-myoepithelial carcinoma of salivary gland (EMC-SG) have not been defined well due to its rarity. The purpose of this study is to assess the proportion of EMC-SG among salivary gland cancers, describe the clinicopathological features and prognosis of this disease, further analyze the factors associated with EMC-SG survival, and establish individual survival-predicting models.
Methods: Data on patients diagnosed with salivary gland malignancy between 2000 and 2020 were collected from the Surveillance, Epidemiology, and End Results database.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!