AI Article Synopsis
- Metastatic breast cancer has a low 5-year survival rate of 21%, making effective symptom management and survival extension crucial for patients.
- Single-agent chemotherapy, like capecitabine, is often preferable due to the severe side effects of multi-drug regimens.
- A study of 26 patients using a combined treatment of 5-fluorouracil and sodium folinate showed an 8.6-month progression-free survival and an 18.5-month overall survival, with manageable side effects, suggesting a viable alternative to traditional options.
Article Abstract
Background/aim: Prognosis of metastatic breast cancer is poor with a 5-year survival rate of 21%. Even though it is incurable, the majority of patients needs a treatment to ameliorate symptoms and prolong survival. If chemotherapy is indicated, toxicity of multi-drug regimens often out-weighs the possible gain, making single-agent chemotherapy the preferred choice. Although capecitabine is frequently used for the treatment of metastatic breast cancer, it is not a therapeutic option for all patients.
Patients And Methods: Since simultaneous application of 5-fluorouracil (5-FU) and sodium folinate is a promising alternative treatment for certain patients, we reviewed the cases of 26 patients treated at our site.
Results: Progression-free survival (PFS) was 8.6 months and overall survival (OS) was 18.5 months with a beneficial toxicity profile.
Conclusion: The efficacy of simultaneous high level 5-FU and sodium folinate is comparable to other frequently used single-agent chemotherapies, while the toxicity profile is favorable.
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