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Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death.
Autophagy
December 2024
Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université Paris Cité, Équipe labellisée par la Ligue contre le Cancer, Institut Universitaire de France, Paris, France.
Cholesterol serves as a vital lipid that regulates numerous physiological processes. Nonetheless, its role in regulating cell death processes remains incompletely understood. In this study, we investigated the role of cholesterol trafficking in immunogenic cell death.
View Article and Find Full Text PDFComparative in vitro hepatic clearances of commonly used antidepressants, antipsychotics, and anti-inflammatory agents in rainbow trout liver S9 fractions.
Aquat Toxicol
September 2024
Faculty of Pharmacy, Drug Research Program, University of Helsinki, Viikinkaari 5E, 00790 Helsinki, Finland; Helsinki Institute of Sustainability Science, University of Helsinki, Yliopistonkatu 3, 00100 Helsinki, Finland. Electronic address:
Article Synopsis
- - Human pharmaceuticals are commonly found in surface waters and can accumulate in aquatic animals, particularly fish, raising concerns about their environmental impact and potential health risks.
- - This study examined the metabolism of twelve pharmaceuticals in rainbow trout liver using test guidance from the OECD, focusing on their intrinsic clearance and the influence of cytochrome P450 enzymes.
- - It was found that several pharmaceuticals, including levomepromazine and sertraline, are potent inhibitors of specific cytochrome P450 activities, which may affect their clearance rates in fish, indicating potential risks when these compounds are present together in the environment.
Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants.
Viruses
March 2024
Department of Infectious Diseases, West German Centre of Infectious Diseases, University Medicine Essen, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.
Article Synopsis
- - The ongoing SARS-CoV-2 pandemic, along with new variants and long-COVID, poses significant challenges, especially in developing countries where healthcare access is limited.
- - Previous research has shown that functional inhibitors of acid sphingomyelinase can effectively combat various viral infections, including some early SARS-CoV-2 variants.
- - A study found that the antidepressants fluoxetine and sertraline can inhibit several SARS-CoV-2 variants in vitro, suggesting they should be considered for large-scale clinical trials as potential COVID-19 treatments.
A Surprising Repurposing of Central Nervous System Drugs against Squamous Cell Carcinoma of the Bladder, UM-UC-5.
Pharmaceutics
January 2024
PerMed Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
The potential benefits of drug repurposing have gained attention as an alternative to developing de novo drugs. The potential of using central nervous system (CNS) drugs as anticancer drugs has been explored in several types of human cancers, such as breast and colon cancer, among others. Here, we examine the effect of the CNS drugs sertraline, paroxetine, and chlorpromazine on human squamous carcinoma cells of the bladder (UM-UC-5).
View Article and Find Full Text PDFFungicide-tolerant persister formation during cryptococcal pulmonary infection.
Cell Host Microbe
February 2024
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Bacterial persisters, a subpopulation of genetically susceptible cells that are normally dormant and tolerant to bactericides, have been studied extensively because of their clinical importance. In comparison, much less is known about the determinants underlying fungicide-tolerant fungal persister formation in vivo. Here, we report that during mouse lung infection, Cryptococcus neoformans forms persisters that are highly tolerant to amphotericin B (AmB), the standard of care for treating cryptococcosis.
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